PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle (Q33341346)

25 July 2017

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title

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle (English)

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25 July 2017

Lily Q Dong

1

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PubMed ID

16014356

25 July 2017

Feng Liu

series ordinal

2

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25 July 2017

1 August 2005

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American Journal of Physiology - Endocrinology and Metabolism

25 July 2017

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25 July 2017

289

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25 July 2017

E187-96

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25 July 2017

2

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

25 July 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Role of translocation in the activation and function of protein kinase B

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Protein kinase C modulates the insulin-stimulated increase in Akt1 and Akt3 activity in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

PDK2: a complex tail in one Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Akt2, a novel functional link between p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Integrin-linked kinase regulates chondrocyte shape and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Characterization of PDK2 activity against protein kinase B gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Crystal structure of an inactive Akt2 kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Altered insulin signaling in retinal tissue in diabetic states

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

PDK1, the master regulator of AGC kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Protein kinase C: structure, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Phosphorylation and activation of p70s6k by PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Unravelling the activation mechanisms of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

The DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00011.2005

10.1152/AJPENDO.00011.2005

21 January 2018

Identifiers

DOI

1 reference

25 July 2017

1 reference

PubMed ID

16014356