Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities (Q33359658)

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English	Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities	scientific article

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scholarly article

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Europe PubMed Central

26 July 2017

Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities (English)

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Europe PubMed Central

26 July 2017

Jeffrey R. Deschamps

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Jeffrey R Deschamps

22

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Adriana Haimovitz-Friedman

19

object named as

Adriana Haimovitz-Friedman

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Europe PubMed Central

26 July 2017

Damon A. Parrish

21

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Damon A Parrish

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26 July 2017

author name string

Dehui Duan

1

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26 July 2017

Dina M Sigano

2

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26 July 2017

James A Kelley

3

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26 July 2017

Christopher C Lai

4

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26 July 2017

Nancy E Lewin

5

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26 July 2017

Noemi Kedei

6

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26 July 2017

Megan L Peach

7

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26 July 2017

Jeewoo Lee

8

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26 July 2017

Thushara P Abeyweera

9

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26 July 2017

Susan A Rotenberg

10

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26 July 2017

Hee Kim

11

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26 July 2017

Young Ho Kim

12

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26 July 2017

Saïd El Kazzouli

13

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26 July 2017

Jae-Uk Chung

14

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26 July 2017

Howard A Young

15

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26 July 2017

Matthew R Young

16

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26 July 2017

Alyson Baker

17

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26 July 2017

Nancy H Colburn

18

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26 July 2017

Jean-Philip Truman

20

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26 July 2017

Nicholas A Perry

23

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26 July 2017

Robert J Surawski

24

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26 July 2017

Peter M Blumberg

25

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26 July 2017

Victor E Marquez

26

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26 July 2017

language of work or name

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publication date

13 August 2008

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26 July 2017

Journal of Medicinal Chemistry

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26 July 2017

51

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26 July 2017

17

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Europe PubMed Central

26 July 2017

5198-5220

1 reference

Europe PubMed Central

26 July 2017

PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups

1 reference

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21 June 2018

Design and characterization of a traceable protein kinase Calpha

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21 June 2018

Diacylglycerol, when simplicity becomes complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Protein kinase C as a therapeutic target

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Protein kinase C regulatory domains: the art of decoding many different signals in membranes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

The origin of C1A-C2 interdomain interactions in protein kinase Calpha.

1 reference

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21 June 2018

A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Membrane-protein interactions in cell signaling and membrane trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Diacylglycerols as activators of protein kinase C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

AKAP signalling complexes: focal points in space and time

1 reference

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21 June 2018

Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin

1 reference

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21 June 2018

Membrane domains.

1 reference

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21 June 2018

PKC-interacting proteins: from function to pharmacology

1 reference

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21 June 2018

Diacylglycerol kinases

1 reference

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21 June 2018

Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands

1 reference

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21 June 2018

Model systems, lipid rafts, and cell membranes

1 reference

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21 June 2018

Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Quality control in combinatorial chemistry: determination of the quantity, purity, and quantitative purity of compounds in combinatorial libraries

1 reference

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21 June 2018

[3H]Phorbol 12,13-dibutyrate binding assay for protein kinase C and related proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

1 reference

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21 June 2018

Protein kinase C isoforms and lipid second messengers: a critical nuclear partnership?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Regulation of PKC alpha activity by C1-C2 domain interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Mass spectrometry and combinatorial chemistry: a short outline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Adaptor proteins in protein kinase C-mediated signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Secretase targets for Alzheimer's disease: identification and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Blockade of PKC epsilon activation attenuates phorbol ester-induced increase of alpha-secretase-derived secreted form of amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Regulation of transmitter release by Unc-13 and its homologues

1 reference

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21 June 2018

Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

New insights into the regulation of protein kinase C and novel phorbol ester receptors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

1 reference

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21 June 2018

Structure and functional properties of diacylglycerols in membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Overexpression of protein kinase Calpha in MCF-10A human breast cells engenders dramatic alterations in morphology, proliferation, and motility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

1 reference

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21 June 2018

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

21 June 2018

Effects of dipalmitoylglycerol and fatty acids on membrane structure and protein kinase C activity

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21 June 2018

Protein kinase D: a novel target for diacylglycerol and phorbol esters

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21 June 2018

Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool

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21 June 2018

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

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21 June 2018

Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester

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21 June 2018

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

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21 June 2018

Clonal cell lines from the rat central nervous system.

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21 June 2018

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1 reference

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21 June 2018

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

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21 June 2018

Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA.

1 reference

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21 June 2018

Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors are determined by tumor volume and endocrine and growth factors

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21 June 2018

Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

31 October 2018

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574997

31 October 2018

Amyloid precursor protein processing is separately regulated by protein kinase C and tyrosine kinase in human astrocytes

1 reference

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31 October 2018

Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha

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31 October 2018

12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase.

1 reference

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31 October 2018

AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells.

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31 October 2018

Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: interleukin 2, interferon, and colony stimulating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18698758

12 December 2020

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Rescue from programmed cell death in leukemic and normal myeloid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18698758

12 December 2020

based on heuristic

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Metastatic model for human prostate cancer using orthotopic implantation in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18698758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death induced by ceramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18698758

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based on heuristic

inferred from PubMed ID database lookup

Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18698758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18698758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18698758

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM8001907

1 reference

Europe PubMed Central

26 July 2017

1 reference

Europe PubMed Central

26 July 2017

1 reference

Europe PubMed Central

26 July 2017

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