Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform (Q33371464)

26 July 2017

title

Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform (English)

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26 July 2017

K I Seyb

1

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26 July 2017

E R Schuman

2

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26 July 2017

J Ni

3

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26 July 2017

M M Huang

4

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26 July 2017

M L Michaelis

5

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26 July 2017

M A Glicksman

6

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26 July 2017

publication date

23 September 2008

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Journal of Biomolecular Screening

26 July 2017

published in

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26 July 2017

volume

13

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26 July 2017

issue

9

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26 July 2017

page(s)

870-878

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Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease.

26 July 2017

cites work

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21 June 2018

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Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons.

21 June 2018

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Retinoic acid evoked-differentiation of neuroblastoma cells predominates over growth factor stimulation: an automated image capture and quantitation approach to neuritogenesis

21 June 2018

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A survey of calpain inhibitors

21 June 2018

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Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

21 June 2018

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Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells

21 June 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 June 2018

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Neurotoxicity induces cleavage of p35 to p25 by calpain

21 June 2018

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p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

21 June 2018

1 reference

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 June 2018

1 reference

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Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor binding

21 June 2018

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Alpha-mercaptoacrylic acid derivatives as novel selective calpain inhibitors

21 June 2018

1 reference

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Mechanisms of neuronal degeneration in Alzheimer's disease

21 June 2018

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Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

21 June 2018

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p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

21 June 2018

1 reference

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

21 June 2018

1 reference

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Proteolytic processing of beta-amyloid precursor by calpain I.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754199

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754199

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754199

Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury

21 June 2018

1 reference

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Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.

31 October 2018

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Evaluation of beta-amyloid peptide 25-35 on calcium homeostasis in cultured rat dorsal root ganglion neurons

31 October 2018

1 reference

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Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754199

Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754199

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754199

Pretreatment with Calpain Inhibitor CEP-4143 Inhibits Calpain I Activation and Cytoskeletal Degradation, Improves Neurological Function, and Enhances Axonal Survival After Traumatic Spinal Cord Injury

31 October 2018

1 reference

12 December 2020

Possible role of calpain in normal processing of beta-amyloid precursor protein in human platelets

1 reference

12 December 2020

Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25

1 reference

12 December 2020

Peptidyl diazomethanes as inhibitors of cysteine and serine proteinases

1 reference

12 December 2020

Identifiers

DOI

10.1177/1087057108323909

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26 July 2017

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26 July 2017

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