Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. (Q44451960)

3 December 2017

Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease (English)

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12 May 2020

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10

Serge Przedborski

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PubMed ID

12764095

3 December 2017

Vernice Jackson-Lewis

3

object named as

Vernice Jackson-Lewis

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3 December 2017

Stephen J Crocker

1

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Patrice D Smith

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Wiplore R Lamba

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Shawn P Hayley

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Erich Grimm

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Steve M Callaghan

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Ruth S Slack

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Edon Melloni

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George S Robertson

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Hymie Anisman

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Zul Merali

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12 May 2020

David S Park

14

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12 May 2020

Vernice Jackson-Lewis

3

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12 May 2020

Serge Przedborski

10

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12 May 2020

language of work or name

English

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publication date

1 May 2003

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3 December 2017

Journal of Neuroscience

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12 May 2020

volume

23

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12 May 2020

page(s)

4081-4091

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12 May 2020

issue

10

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Modulation of GABA release by dopamine in the substantia nigra.

12 May 2020

cites work

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12 December 2020

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

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12 December 2020

Sensitization to the effects of tumor necrosis factor-alpha: neuroendocrine, central monoamine, and behavioral variations.

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12 December 2020

The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease.

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12 December 2020

DeltaFosB: a molecular mediator of long-term neural and behavioral plasticity

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12 December 2020

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

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12 December 2020

Striatal fosB expression is causally linked with l-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

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12 December 2020

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

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12 December 2020

Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

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12 December 2020

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

12 December 2020

The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited.

1 reference

12 December 2020

Mitochondrial dysfunction in Parkinson's disease.

1 reference

12 December 2020

The calpain small subunit gene is essential: its inactivation results in embryonic lethality.

1 reference

12 December 2020

5-HT2C receptor binding is increased in the substantia nigra pars reticulata in Parkinson's disease

1 reference

12 December 2020

Dopamine in dendrites of substantia nigra neurons: suggestions for a role in dendritic terminals.

1 reference

12 December 2020

Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

1 reference

12 December 2020

Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating.

1 reference

12 December 2020

Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells

1 reference

12 December 2020

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

1 reference

12 December 2020

The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety

1 reference

12 December 2020

Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

1 reference

12 December 2020

Experimental models of Parkinson's disease

1 reference

12 December 2020

Increased plasma neurotensin concentrations in patients with Parkinson's disease

1 reference

12 December 2020

Dopamine denervation induces neurotensin immunoreactivity in GABA-parvalbumin striatal neurons.

1 reference

12 December 2020

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

1 reference

12 December 2020

Calpain function in the modulation of signal transduction molecules

1 reference

12 December 2020

An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

1 reference

12 December 2020

NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease.

1 reference

12 December 2020

Behavioral phenotyping of the MPTP mouse model of Parkinson's disease

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12 December 2020

c-Jun mediates axotomy-induced dopamine neuron death in vivo

1 reference

12 December 2020

Endoplasmic reticulum dysfunction--a common denominator for cell injury in acute and degenerative diseases of the brain?

1 reference

12 December 2020

Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease

1 reference

12 December 2020

Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease

1 reference

12 December 2020

Complex I and Parkinson's disease

1 reference

12 December 2020

Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain

1 reference

12 December 2020

Dopamine modulates the function of group II and group III metabotropic glutamate receptors in the substantia nigra pars reticulata

1 reference

12 December 2020

Free radical and nitric oxide toxicity in Parkinson's disease.

1 reference

12 December 2020

Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion

1 reference

12 December 2020

Modulation of cellular signals by calpain

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12 December 2020

Dopaminergic neurons expressing calbindin in normal and parkinsonian monkeys.

1 reference

12 December 2020

Degradation of transcription factors, c-Jun and c-Fos, by calpain

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12 December 2020

In vivo neurochemical and behavioural effects of intracerebrally administered neurotensin and D-Trp11-neurotensin on mesolimbic and nigrostriatal dopaminergic function in the rat.

1 reference

12 December 2020

Effects of dopamine D1 and D2 receptor agonists and antagonists on bombesin-induced behaviors

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12 December 2020

Estimation of nuclear population from microtome sections

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12 December 2020

Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K.

1 reference

12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

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12 December 2020

Evidence that L-dopa-induced rotational behavior is dependent on both striatal and nigral mechanisms

1 reference

12 December 2020

Comparison of changes in locomotor activity with striatal homovanillic acid and 3,4-dihydroxyphenylacetic acid concentrations following the bilateral intranigral injection of dopamine agonist drugs in rats

1 reference

12 December 2020

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

1 reference

12 December 2020

The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium

1 reference

12 December 2020

Endogenous inhibitor for calcium-dependent cysteine protease contains four internal repeats that could be responsible for its multiple reactive sites

1 reference

12 December 2020

N-methyl-4-phenylpyridine (MMP+) together with 6-hydroxydopamine or dopamine stimulates Ca2+ release from mitochondria

1 reference

12 December 2020

Evidence that the substantia nigra is a site of action for l-DOPA

1 reference

12 December 2020

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

12 December 2020

Dendritic release of dopamine in the substantia nigra

1 reference

12 December 2020

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1 reference

12 December 2020

Changes in extracellular levels of glutamate and aspartate in rat substantia nigra induced by dopamine receptor ligands: in vivo microdialysis studies

1 reference

12 December 2020

Characterization of neurotensin-like immunoreactivity in human basal ganglia: increased neurotensin levels in substantia nigra in Parkinson's disease

1 reference

12 December 2020

Calpain inhibition: an overview of its therapeutic potential

1 reference

12 December 2020

Adenoviral vectors as functional retrograde neuronal tracers.

1 reference

12 December 2020

Localization of mRNAs for calpain and calpastatin in the adult rat brain by in situ hybridization histochemistry.

1 reference

12 December 2020

Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain.

1 reference

12 December 2020

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

1 reference

12 December 2020

Regional distribution of monoamine vesicular uptake sites in the mesencephalon of control subjects and patients with Parkinson's disease: a postmortem study using tritiated tetrabenazine

1 reference

12 December 2020

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

1 reference

12 December 2020

Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of deltaFosB-like protein(s) in both the rodent and primate striatum

1 reference

12 December 2020

Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord

1 reference

12 December 2020

Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?

1 reference

12 December 2020

Role of nitric oxide in neurodegenerative diseases.

1 reference

12 December 2020

Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

1 reference

12 December 2020

MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/Bl6 mice

1 reference

12 December 2020

GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine.

1 reference

12 December 2020

Construction of adenovirus vectors through Cre-lox recombination

1 reference

12 December 2020

Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease

1 reference

12 December 2020

On the involvement of calpains in the degradation of the tumor suppressor protein p53

1 reference

12 December 2020

Neuronal vulnerability in Parkinson's disease.

1 reference

12 December 2020

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1 reference

12 December 2020

Glial cell line-derived neurotrophic factor attenuates behavioural deficits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopamine-lesioned adult rats: comparison of intraventricular and intranigral delivery

1 reference

12 December 2020

Structure and physiological function of calpains

1 reference

12 December 2020

The regulation of motor control: an evaluation of the role of dopamine receptors in the substantia nigra

1 reference

12 December 2020

Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats

1 reference

12 December 2020

MPTP-Parkinsonism is accompanied by persistent expression of a delta-FosB-like protein in dopaminergic pathways.

1 reference

12 December 2020

1 reference

12 December 2020

Rat brain contains multiple mRNAs for calpastatin.

1 reference

12 December 2020

Calbindin-D28k buffers intracellular calcium and promotes resistance to degeneration in PC12 cells.

1 reference

12 December 2020

Behavioral effects of 5-HT2C receptor antagonism in the substantia nigra zona reticulata of the 6-hydroxydopamine-lesioned rat model of Parkinson's disease.

1 reference

12 December 2020

Oxidative mechanisms in nigral cell death in Parkinson's disease.

1 reference

12 December 2020

Calpain: a protease in search of a function?

1 reference

12 December 2020

Properties of calpastatin forms in rat brain.

1 reference

12 December 2020

Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions

1 reference

12 December 2020

Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'.

1 reference

12 December 2020

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.

1 reference

12 December 2020

Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity

1 reference

12 December 2020

CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.

1 reference

12 December 2020

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism.

1 reference

12 December 2020

10.1523/JNEUROSCI.23-10-04081.2003

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741113&resulttype=core&format=json

12 May 2020

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12 May 2020

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