Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment (Q33382120)

26 July 2017

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment (English)

1 reference

26 July 2017

Ottavio Arancio

5

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author name string

Tao Yang

1

1 reference

26 July 2017

Juliet K Knowles

2

1 reference

26 July 2017

Qun Lu

3

1 reference

26 July 2017

Hong Zhang

4

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26 July 2017

Laura A Moore

6

1 reference

26 July 2017

Timothy Chang

7

1 reference

26 July 2017

Qian Wang

8

1 reference

26 July 2017

Katrin Andreasson

9

1 reference

26 July 2017

Jayakumar Rajadas

10

1 reference

26 July 2017

Gerald G Fuller

11

1 reference

26 July 2017

Youmei Xie

12

1 reference

26 July 2017

Stephen M Massa

13

1 reference

26 July 2017

Frank M Longo

14

1 reference

26 July 2017

language of work or name

English

0 references

publication date

3 November 2008

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26 July 2017

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26 July 2017

3

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26 July 2017

e3604

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26 July 2017

11

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Creative Commons CC0 License

26 July 2017

start time

3 November 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

Small molecule modulation of p75 neurotrophin receptor functions

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Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms

21 June 2018

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The function of p75NTR in glia

21 June 2018

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A cyclic peptide that binds p75(NTR) protects neurones from beta amyloid (1-40)-induced cell death.

21 June 2018

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JNK signalling: a possible target to prevent neurodegeneration.

21 June 2018

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Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.

21 June 2018

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

21 June 2018

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

21 June 2018

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Lipid-induced beta-amyloid peptide assemblage fragmentation

21 June 2018

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Does the p75 neurotrophin receptor mediate Abeta-induced toxicity in Alzheimer's disease?

21 June 2018

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Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3beta and stimulate axonal growth

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

21 June 2018

1 reference

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Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance

21 June 2018

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Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism

21 June 2018

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Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor

21 June 2018

1 reference

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Cdk5 deregulation in the pathogenesis of Alzheimer's disease

21 June 2018

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Leukocyte Antigen-Related Protein Tyrosine Phosphatase Receptor: A Small Ectodomain Isoform Functions as a Homophilic Ligand and Promotes Neurite Outgrowth

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

21 June 2018

1 reference

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Neurotrophin signaling through the p75 neurotrophin receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Calpain and caspase: can you tell the difference?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Relationship of Intracellular Calcium to Dependence on Nerve Growth Factor in Dorsal Root Ganglion Neurons in Cell Culture

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease

21 June 2018

1 reference

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c-Jun phosphorylation in Alzheimer disease.

21 June 2018

1 reference

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Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003604

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003604

Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003604

Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003604

Beta-amyloid peptide toxicity in organotypic hippocampal slice culture involves Akt/PKB, GSK-3beta, and PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003604

Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003604

Antagonistic effects of TrkB and p75(NTR) on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003604

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003604

Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003604

Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575383

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

31 October 2018

1 reference

12 December 2020

Rapid increase in immunoreactivity to GFAP in astrocytes in vitro induced by acidic pH is mediated by calcium influx and calpain I

1 reference

12 December 2020

Neurotrophins induce death of hippocampal neurons via the p75 receptor

1 reference

12 December 2020

Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0003604

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DOI

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26 July 2017

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26 July 2017

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