Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease. (Q48496690)

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scientific article published in June 2006

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English	Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.	scientific article published in June 2006

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30 January 2020

Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease (English)

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30 January 2020

Alzheimer's disease

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Matthias Staufenbiel

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Matthias Staufenbiel

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12 February 2018

http://europepmc.org/abstract/MED/16775141

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Lorena Heredia

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30 January 2020

Pablo Helguera

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30 January 2020

Soledad de Olmos

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30 January 2020

Gabriela Kedikian

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30 January 2020

Francisco Solá Vigo

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30 January 2020

Frank LaFerla

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30 January 2020

José de Olmos

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30 January 2020

Jorge Busciglio

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30 January 2020

Alfredo Cáceres

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30 January 2020

Alfredo Lorenzo

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30 January 2020

Matthias Staufenbiel

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30 January 2020

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1 June 2006

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30 January 2020

Journal of Neuroscience

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30 January 2020

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30 January 2020

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30 January 2020

6533-6542

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30 January 2020

Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Abeta42 accumulation in human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative stimuli induce persistent ADF/cofilin-actin rods that disrupt distal neurite function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Making memories stick: cell-adhesion molecules in synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paxillin interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin connections map: to infinity and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of a fibrillar amyloid beta-protein binding domain on its precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of neuronal dystrophy induced by fibrillar amyloid beta: implications for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling mechanisms that regulate actin-based motility processes in the nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADF/cofilin and actin dynamics in disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate and Amyloid β-Protein Rapidly Inhibit Fast Axonal Transport in Cultured Rat Hippocampal Neurons by Different Mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methodological variables in the assessment of beta amyloid neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LIM kinase 1, a key regulator of actin dynamics, is widely expressed in embryonic and adult tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid beta precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal structure is altered by amyloid plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuritic pathology and dementia in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coagulation Factor XIa Cleaves the RHDS Sequence and Abolishes the Cell Adhesive Properties of the Amyloid β-Protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochalasins protect hippocampal neurons against amyloid beta-peptide toxicity: evidence that actin depolymerization suppresses Ca2+ influx.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of beta-amyloid peptides with integrins in a human nerve cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-like dystrophic neurites characteristically associated with senile plaques are not found within other neurodegenerative diseases unless amyloid beta-protein deposition is present.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16775141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5567-05.2006

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30 January 2020

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30 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16775141%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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