The UPS: a promising target for breast cancer treatment. (Q33384289)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19007432%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

review article

2 references

19 July 2021

The UPS: a promising target for breast cancer treatment (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19007432%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

19 July 2021

1 reference

22 December 2019

proteasome endopeptidase complex

1 reference

19 July 2021

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19007432%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Ko Sato

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19007432%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Tomohiko Ohta

series ordinal

3

1 reference

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17 January 2020

language of work or name

1 reference

21 October 2008

8 references

13 March 2019

3 April 2019

17 June 2019

28 September 2019

16 November 2019

22 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19007432%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

19 July 2021

8 references

13 March 2019

3 April 2019

17 June 2019

28 September 2019

16 November 2019

22 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19007432%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

19 July 2021

9 Suppl 1

1 reference

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17 January 2020

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S2

1 reference

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Creative Commons Attribution 2.0 Generic

17 January 2020

copyright license

7 references

13 March 2019

3 April 2019

17 June 2019

28 September 2019

16 November 2019

22 December 2019

on focus list of Wikimedia project

19 July 2021

copyright status

copyrighted

0 references

ScienceSource

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BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

21 June 2018

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A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

21 June 2018

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21 June 2018

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Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers

21 June 2018

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Bortezomib (VELCADE) in metastatic breast cancer: pharmacodynamics, biological effects, and prediction of clinical benefits

21 June 2018

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Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility

21 June 2018

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

21 June 2018

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A genomic and functional inventory of deubiquitinating enzymes

21 June 2018

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21 June 2018

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

21 June 2018

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21 June 2018

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Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype

21 June 2018

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21 June 2018

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Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials

21 June 2018

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21 June 2018

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Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer.

21 June 2018

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21 June 2018

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Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor

21 June 2018

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21 June 2018

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BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

21 June 2018

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Coactivator AIB1 links estrogen receptor transcriptional activity and stability

21 June 2018

1 reference

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Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase

21 June 2018

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CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies

21 June 2018

1 reference

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Ubiquitin and breast cancer

21 June 2018

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BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

21 June 2018

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Back to the future with ubiquitin

21 June 2018

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Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase

21 June 2018

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Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer

21 June 2018

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The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

21 June 2018

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Repeated observation of breast tumor subtypes in independent gene expression data sets

21 June 2018

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21 June 2018

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The proteasome: structure, function, and role in the cell

21 June 2018

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Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

21 June 2018

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Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling

21 June 2018

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Negative receptor signalling

21 June 2018

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The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes

21 June 2018

1 reference

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ErbB2 degradation mediated by the co-chaperone protein CHIP

21 June 2018

1 reference

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Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

21 June 2018

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Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

21 June 2018

1 reference

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Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

21 June 2018

1 reference

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Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

21 June 2018

1 reference

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Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

21 June 2018

1 reference

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Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase

21 June 2018

1 reference

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NF-kappa B as a therapeutic target in multiple myeloma

21 June 2018

1 reference

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Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes.

21 June 2018

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Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

21 June 2018

1 reference

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The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

21 June 2018

1 reference

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 June 2018

1 reference

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Ongoing and planned adjuvant trials with trastuzumab.

21 June 2018

1 reference

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MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells

21 June 2018

1 reference

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Lessons learned from BRCA1 and BRCA2.

21 June 2018

1 reference

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Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

21 June 2018

1 reference

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The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

21 June 2018

1 reference

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Molecular portraits of human breast tumours

21 June 2018

1 reference

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The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.

21 June 2018

1 reference

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The ErbB signaling network: receptor heterodimerization in development and cancer

21 June 2018

1 reference

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Rab7: a key to lysosome biogenesis

21 June 2018

1 reference

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Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

21 June 2018

1 reference

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Eponemycin exerts its antitumor effect through the inhibition of proteasome function.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Proteasome-dependent degradation of the human estrogen receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

21 June 2018

1 reference

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 June 2018

1 reference

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ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

The incidence and gene frequency of ataxia-telangiectasia in the United States

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Epoxomicin, a new antitumor agent of microbial origin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Haplo-insufficiency of BRCA1 in sporadic breast cancer

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Methylation of the BRCA1 gene in sporadic breast cancer

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2582803

Expression of survivin and its relationship to loss of apoptosis in breast carcinomas

31 October 2018

1 reference

12 December 2020

Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity

1 reference

12 December 2020

The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators

1 reference

12 December 2020

Various phosphorylation pathways, depending on agonist and antagonist binding to endogenous estrogen receptor alpha (ERalpha), differentially affect ERalpha extractability, proteasome-mediated stability, and transcriptional activity in human breast

1 reference

12 December 2020

Proteasome inhibitor drugs on the rise

1 reference

12 December 2020

EGFR gene and protein expression in breast cancers

1 reference

12 December 2020

10.1186/1471-2091-9-S1-S2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19007432%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 January 2020

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-2091-9-s1-s2

9 September 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19007432%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

19007432

1 reference