pRb and E2f-1 in mouse development and tumorigenesis (Q33540076)

27 July 2017

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title

pRb and E2f-1 in mouse development and tumorigenesis (English)

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27 July 2017

Macleod K

1

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27 July 2017

1 February 1999

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Current Opinion in Genetics & Development

27 July 2017

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27 July 2017

9

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27 July 2017

31-39

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27 July 2017

1

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The regulation of E2F by pRB-family proteins

27 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

The retinoblastoma gene family: cousins with overlapping interests.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

An E2F-like repressor of transcription.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

E2F-6, a member of the E2F family that can behave as a transcriptional repressor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

E2F activity is regulated by cell cycle-dependent changes in subcellular localization

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Retinoblastoma protein recruits histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Rb interacts with histone deacetylase to repress transcription

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Distinct roles for E2F proteins in cell growth control and apoptosis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Effects of an Rb mutation in the mouse

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Requirement for a functional Rb-1 gene in murine development

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Targeted disruption of p107: functional overlap between p107 and Rb

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Shared role of the pRB-related p130 and p107 proteins in limb development

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

The retinoblastoma gene family is differentially expressed during embryogenesis.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

E2F-1 functions in mice to promote apoptosis and suppress proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Oncogenic capacity of the E2F1 gene

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Traps to catch unwary oncogenes

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

p19ARF links the tumour suppressor p53 to Ras

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980005-7

7 January 2021

10.1016/S0959-437X(99)80005-7

Identifiers

DOI

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27 July 2017

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PubMed ID

10072353