The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus (Q33591069)

28 July 2017

The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus (English)

1 reference

28 July 2017

1 reference

Marc Ehlers

6

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author name string

Monica Zamisch

1

1 reference

28 July 2017

Linhua Tian

2

1 reference

28 July 2017

Roland Grenningloh

3

1 reference

28 July 2017

Yumei Xiong

4

1 reference

28 July 2017

Kathryn F Wildt

5

1 reference

28 July 2017

I-Cheng Ho

7

1 reference

28 July 2017

Rémy Bosselut

8

1 reference

28 July 2017

language of work or name

English

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publication date

16 November 2009

1 reference

Journal of Experimental Medicine

28 July 2017

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28 July 2017

206

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28 July 2017

12

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28 July 2017

2685-2699

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CD4-CD8 lineage differentiation: Thpok-ing into the nucleus

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Thymomegaly, microsplenia, and defective homeostatic proliferation of peripheral lymphocytes in p51-Ets1 isoform-specific null mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Journey through the thymus: stromal guides for T-cell development and selection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

A guide to choosing fluorescent proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Transcriptional regulation of human CD5: important role of Ets transcription factors in CD5 expression in T cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Critical roles for transcription factor GATA-3 in thymocyte development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Positive and negative selection of T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

When Ets transcription factors meet their partners

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

The regulation of CD5 expression in murine T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

AML1 haploinsufficiency, gene dosage, and the predisposition to acute leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Several different cell surface molecules control negative selection of medullary thymocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

ETS-core binding factor: a common composite motif in antigen receptor gene enhancers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

T cell receptor antagonist peptides induce positive selection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Defective activation and survival of T cells lacking the Ets-1 transcription factor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Molecular and cellular events of T cell development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Identification of a Ets1 variant protein unaffected in its chromatin and in vitro DNA binding capacities by T cell antigen receptor triggering and intracellular calcium rises

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

A phorbol ester response element within the human T-cell receptor beta-chain enhancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806616

Impaired generation of CD8+ thymocytes in Ets-1-deficient mice.

21 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

Role of Ets-1 phosphorylation in the effector function of Th cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

CD69 expression during selection and maturation of CD4+8+ thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092024

Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1)

21 January 2018

1 reference

12 December 2020

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

1 reference

12 December 2020

The ETS-domain transcription factor family

1 reference

12 December 2020

Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage

1 reference

12 December 2020

The Ets-1 transcription factor is required for the development of natural killer cells in mice

1 reference

12 December 2020

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

1 reference

12 December 2020

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20092024

1 reference

28 July 2017

1 reference

28 July 2017

1 reference