CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals (Q35824059)

10 August 2017

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title

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals (English)

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10 August 2017

Rémy Bosselut

1

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PubMed ID

15229472

10 August 2017

language of work or name

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1 July 2004

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Nature Reviews Immunology

10 August 2017

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10 August 2017

4

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10 August 2017

529-540

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10 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nri1392

10 August 2017

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Accessories or coreceptors?

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31 March 2020

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The CD8alpha gene locus is regulated by the Ikaros family of proteins.

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31 March 2020

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An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

31 March 2020

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Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

31 March 2020

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A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development

31 March 2020

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Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength

31 March 2020

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Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

31 March 2020

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Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

31 March 2020

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31 March 2020

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31 March 2020

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

31 March 2020

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31 March 2020

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The constantly changing face of chromatin

31 March 2020

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31 March 2020

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31 March 2020

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

31 March 2020

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31 March 2020

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Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

31 March 2020

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Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development

31 March 2020

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Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.

31 March 2020

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31 March 2020

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Distinct in vivo requirements for establishment versus maintenance of transcriptional repression.

31 March 2020

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31 March 2020

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Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates

31 March 2020

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Regulation of chromatin remodeling by inositol polyphosphates

31 March 2020

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31 March 2020

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Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction

31 March 2020

1 reference

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

31 March 2020

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Unravelling heterochromatin: competition between positive and negative factors regulates accessibility

31 March 2020

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Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner

31 March 2020

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Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage

31 March 2020

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The lineage decisions of helper T cells

31 March 2020

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GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

31 March 2020

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Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

31 March 2020

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GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation

31 March 2020

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Studies on T cell maturation on defined thymic stromal cell populations in vitro

31 March 2020

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Critical roles for transcription factor GATA-3 in thymocyte development

31 March 2020

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Signal strength in thymic selection and lineage commitment.

31 March 2020

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The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex

31 March 2020

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

31 March 2020

1 reference

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

31 March 2020

1 reference

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

31 March 2020

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The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

31 March 2020

1 reference

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

31 March 2020

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The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells

31 March 2020

1 reference

Lck activity controls CD4/CD8 T cell lineage commitment.

31 March 2020

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Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus.

31 March 2020

1 reference

The influence of the MAPK pathway on T cell lineage commitment

31 March 2020

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Role of TCR zeta chain in T cell development and selection

31 March 2020

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Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

31 March 2020

1 reference

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

31 March 2020

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Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

31 March 2020

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Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection

31 March 2020

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A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

31 March 2020

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

31 March 2020

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Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes

31 March 2020

1 reference

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

31 March 2020

1 reference

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

31 March 2020

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Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

31 March 2020

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

31 March 2020

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Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection

31 March 2020

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Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

31 March 2020

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Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8(+) T cell differentiation in the thymus

31 March 2020

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New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

31 March 2020

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CD8 lineage commitment in the absence of CD8.

31 March 2020

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Csk controls antigen receptor-mediated development and selection of T-lineage cells.

31 March 2020

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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

31 March 2020

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Essential role of Stat6 in IL-4 signalling

31 March 2020

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Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

31 March 2020

1 reference

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

31 March 2020

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The influence of the thymic environment on the CD4-versus-CD8 T lineage decision.

31 March 2020

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TOX provides a link between calcineurin activation and CD8 lineage commitment

31 March 2020

1 reference

The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression

31 March 2020

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Regulation of lineage commitment distinct from positive selection.

31 March 2020

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Core-binding factors in haematopoiesis and leukaemia

31 March 2020

1 reference

Mechanisms of transcriptional regulation by Runt domain proteins

31 March 2020

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Thymocytes control the CD4 gene differently from mature T lymphocytes

31 March 2020

1 reference

Hierarchical interactions control CD4 gene expression during thymocyte development.

31 March 2020

1 reference

Identification and characterization of a human CD4 silencer

31 March 2020

1 reference

Negative regulation of CD4 gene expression by a HES-1-c-Myb complex

31 March 2020

1 reference

Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment.

31 March 2020

1 reference

CD69 expression during selection and maturation of CD4+8+ thymocytes.

31 March 2020

1 reference

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells

31 March 2020

1 reference

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment.

31 March 2020

1 reference

Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling.

31 March 2020

1 reference

Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development.

31 March 2020

1 reference

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Identifiers

DOI

10.1038/NRI1392

1 reference

PubMed ID

15229472

Dimensions Publication ID

10 August 2017

0 references

1 reference

PubMed ID

15229472