CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision (Q35769448)

10 August 2017

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title

CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision (English)

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10 August 2017

0 references

1 reference

Alfred Singer

1

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10 August 2017

Remy Bosselut

series ordinal

2

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10 August 2017

publication date

1 January 2004

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10 August 2017

published in

Advances in Immunology

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10 August 2017

volume

83

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10 August 2017

page(s)

91-131

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A critical role for the cytoplasmic tail of pTα in T lymphocyte development

10 August 2017

cites work

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7 January 2021

Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells

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7 January 2021

Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

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7 January 2021

Evidence for a differential avidity model of T cell selection in the thymus

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7 January 2021

A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice.

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7 January 2021

Asynchronous coreceptor downregulation after positive thymic selection: prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor

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7 January 2021

Differentiation of CD4(high)CD8(low) coreceptor-skewed thymocytes into mature CD8 single-positive cells independent of MHC class I recognition.

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7 January 2021

A subset of CD4+ thymocytes selected by MHC class I molecules

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7 January 2021

Mouse CD1-specific NK1 T cells: development, specificity, and function

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7 January 2021

CD8/CD4 lineage commitment occurs by an instructional/default process followed by positive selection.

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7 January 2021

Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment.

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7 January 2021

Gene transfer of the Ly-3 chain gene of the mouse CD8 molecular complex: co-transfer with the Ly-2 polypeptide gene results in detectable cell surface expression of the Ly-3 antigenic determinants.

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7 January 2021

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus.

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7 January 2021

Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4.

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7 January 2021

Blockage of alpha beta T-cell development by TCR gamma delta transgenes

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7 January 2021

Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes

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7 January 2021

Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells

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7 January 2021

Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus

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7 January 2021

Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction

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7 January 2021

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression

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7 January 2021

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

1 reference

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7 January 2021

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

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7 January 2021

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice

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7 January 2021

Another view of the selective model of thymocyte selection.

1 reference

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7 January 2021

CD8 coreceptor extinction in signaled CD4(+)CD8(+) thymocytes: coordinate roles for both transcriptional and posttranscriptional regulatory mechanisms in developing thymocytes

1 reference

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7 January 2021

Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals

1 reference

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7 January 2021

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

The Shaping of the T Cell Repertoire

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7 January 2021

Mice lacking MHC class II molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Thymocyte lineage commitment: is it instructed or stochastic?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Transfection of the CD8 gene enhances T-cell recognition.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Human CD8 beta, but not mouse CD8 beta, can be expressed in the absence of CD8 alpha as a beta beta homodimer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Interaction between CD4 and class II MHC molecules mediates cell adhesion

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Kinetics of mature T-cell development in the thymus

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

CD8 is needed for development of cytotoxic T cells but not helper T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Control points in early T-cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

CD8 lineage commitment in the absence of CD8.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.

1 reference

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7 January 2021

Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells

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7 January 2021

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Lck activity controls CD4/CD8 T cell lineage commitment.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

T cell receptor antagonist peptides induce positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Stochastic component to development of class I major histocompatibility complex-specific T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Deciphering the role of Notch signaling in lymphopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Accessories or coreceptors?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

T cell tolerance by clonal elimination in the thymus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Extensive proliferation of T cell lineage-restricted progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor beta chains.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

1 reference

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7 January 2021

Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function

1 reference

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7 January 2021

Notch cleavage: Nicastrin helps Presenilin make the final cut.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

The Lyt-2, Lyt-3 macromolecules: structural and functional studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

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7 January 2021

Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection

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7 January 2021

The absence of Itk inhibits positive selection without changing lineage commitment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Development of CD4-CD8+ cytotoxic T cells requires interactions with class I MHC determinants

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

How many thymocytes audition for selection?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: rescue of CD4 T cell lineage without co-engagement of TcR/CD4 by MHC class II.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

A second subunit of CD8 is expressed in human T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

In vitro differentiation and commitment of CD4+ CD8+ thymocytes to the CD4 lineage, without TCR engagement.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Disruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4(+) T cells in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

The level of CD8 expression can determine the outcome of thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Analysis and expression of a cloned pre-T cell receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Tec family kinases modulate thresholds for thymocyte development and selection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Csk controls antigen receptor-mediated development and selection of T-lineage cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Positive and negative selection of an antigen receptor on T cells in transgenic mice.

1 reference

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7 January 2021

The influence of the MAPK pathway on T cell lineage commitment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Role of TCR zeta chain in T cell development and selection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Expression and function of the interleukin 7 receptor in murine lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Positive selection of CD4+ T cells by TCR-specific antibodies requires low valency TCR cross-linking: implications for repertoire selection in the thymus.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

CD69 expression during selection and maturation of CD4+8+ thymocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Post-transcriptional regulation of early T cell development by T cell receptor signals

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Participation of CD4 coreceptor molecules in T-cell repertoire selection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Development of mature CD8+ thymocytes: selection rather than instruction?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

The MHC reactivity of the T cell repertoire prior to positive and negative selection.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983003-7

7 January 2021

10.1016/S0065-2776(04)83003-7

Identifiers

DOI

1 reference

10 August 2017

1 reference