Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (Q33621603)

28 July 2017

title

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (English)

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28 July 2017

9

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28 July 2017

Lijian Shao

1

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28 July 2017

Wei Feng

2

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28 July 2017

Hongliang Li

3

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28 July 2017

David Gardner

4

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28 July 2017

Yi Luo

5

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28 July 2017

Yong Wang

6

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28 July 2017

Lingbo Liu

7

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28 July 2017

Aimin Meng

8

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28 July 2017

Daohong Zhou

10

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28 July 2017

language of work or name

English

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publication date

12 March 2014

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28 July 2017

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28 July 2017

volume

123

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28 July 2017

issue

20

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28 July 2017

page(s)

3105-3115

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p21 both attenuates and drives senescence and aging in BubR1 progeroid mice

28 July 2017

cites work

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DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions

21 June 2018

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Hematopoietic stem cell regeneration enhanced by ectopic expression of ROS-detoxifying enzymes in transplant mice

21 June 2018

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Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells

21 June 2018

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A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage

21 June 2018

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21 June 2018

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Inhibition of p38 MAPK attenuates ionizing radiation-induced hematopoietic cell senescence and residual bone marrow injury

21 June 2018

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21 June 2018

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Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression

21 June 2018

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21 June 2018

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Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity

21 June 2018

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Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.

21 June 2018

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Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

21 June 2018

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Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

21 June 2018

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Irradiation selects for p53-deficient hematopoietic progenitors.

21 June 2018

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Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells

21 June 2018

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Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging

21 June 2018

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Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.

21 June 2018

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TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

21 June 2018

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Senescence of activated stellate cells limits liver fibrosis

21 June 2018

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p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

21 June 2018

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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

21 June 2018

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Hematopoietic stem cell exhaustion impacted by p18 INK4C and p21 Cip1/Waf1 in opposite manners

21 June 2018

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Total body irradiation selectively induces murine hematopoietic stem cell senescence

21 June 2018

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A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress

21 June 2018

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Ink4a/Arf expression is a biomarker of aging

21 June 2018

1 reference

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Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

21 June 2018

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Cell cycle inhibitors in normal and tumor stem cells

21 June 2018

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

21 June 2018

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 June 2018

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

21 June 2018

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

21 June 2018

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Tumor suppression by Ink4a-Arf: progress and puzzles

21 June 2018

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Replicative senescence revisited

21 June 2018

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Putting the stress on senescence

21 June 2018

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The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells.

21 June 2018

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21 June 2018

1 reference

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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023419

The INK4A/ARF locus and its two gene products

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023419

Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023419

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 June 2018

1 reference

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Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023419

Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023419

Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023419

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023419

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023419

Granulocyte-colony stimulating factor impedes recovery from damage caused by cytotoxic agents through increased differentiation at the expense of self-renewal

30 October 2018

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12 December 2020

The effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on primitive hematopoietic stem cell (PHSC) function and numbers, after chemotherapy

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12 December 2020

Granulocyte colony-stimulating factor enhances bone marrow stem cell damage caused by repeated administration of cytotoxic agents

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12 December 2020

Real-time PCR assay for measurement of mouse telomeres

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12 December 2020

10.1182/BLOOD-2013-07-515619

Identifiers

DOI

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28 July 2017

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28 July 2017

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