DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions (Q34328242)

1 August 2017

DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions (English)

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1 August 2017

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3

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1 August 2017

Alessandra Insinga

1

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1 August 2017

Angelo Cicalese

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1 August 2017

Barbara Gallo

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1 August 2017

Luisa Albano

5

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1 August 2017

Simona Ronzoni

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1 August 2017

Laura Furia

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1 August 2017

Andrea Viale

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1 August 2017

Pier Giuseppe Pelicci

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1 August 2017

language of work or name

English

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publication date

15 February 2013

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1 August 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

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published in

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1 August 2017

110

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10

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1 August 2017

3931-3936

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describes a project that uses

1 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3593901/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

DNA-damage response in tissue-specific and cancer stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

The first 30 years of p53: growing ever more complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

Tumour suppression by p53: a role for the DNA damage response?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

6 July 2018

1 reference

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Hematopoiesis: an evolving paradigm for stem cell biology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

How stem cells age and why this makes us grow old.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

DNA repair is limiting for haematopoietic stem cells during ageing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

DNA damage-dependent cell cycle checkpoints and genomic stability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning

6 July 2018

1 reference

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The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593901

A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning.

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1213394110

Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1213394110

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1213394110

A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1213394110

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1213394110

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

21 January 2018

1 reference

12 December 2020

Differential DNA damage response in stem and progenitor cells

1 reference

12 December 2020

Delayed kinetics of DNA double-strand break processing in normal and pathological aging

1 reference

12 December 2020

p53 deficiency sensitizes clonogenic cells to irradiation in the large but not the small intestine

1 reference

12 December 2020

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

12 December 2020

Stem cells and DNA damage: persist or perish?

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1213394110

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1 August 2017

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1 August 2017

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