Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease (Q33624303)

28 July 2017

3 references

25 April 2019

20 November 2019

15 December 2019

Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease (English)

1 reference

28 July 2017

3 references

25 April 2019

20 November 2019

15 December 2019

1 reference

20 November 2019

1 reference

15 December 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803226%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

Thomas A Bayer

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803226%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

publication date

7 May 2014

4 references

28 July 2017

25 April 2019

20 November 2019

15 December 2019

Acta Neuropathologica

4 references

25 April 2019

20 November 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803226%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

127

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803226%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803226%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

787-801

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803226%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

2 June 2020

copyright license

start time

7 May 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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21 June 2018

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21 June 2018

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21 June 2018

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Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid

21 June 2018

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The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.

21 June 2018

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Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy

21 June 2018

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Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

21 June 2018

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Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila

21 June 2018

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Use-dependent plasticity in clock neurons regulates sleep need in Drosophila

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 June 2018

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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

21 June 2018

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High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain

21 June 2018

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Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia.

21 June 2018

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Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

21 June 2018

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Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques

21 June 2018

1 reference

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Regulation of NMDA receptor trafficking by amyloid-beta

21 June 2018

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Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

21 June 2018

1 reference

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Quantification of the A beta peptide in Alzheimer's plaques by laser dissection microscopy combined with mass spectrometry

21 June 2018

1 reference

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Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

21 June 2018

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Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach

21 June 2018

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APP processing and synaptic function

21 June 2018

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Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

21 June 2018

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Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

21 June 2018

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

21 June 2018

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Alzheimer's disease: genes, proteins, and therapy

21 June 2018

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 June 2018

1 reference

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

21 June 2018

1 reference

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024135

Increased generation of alternatively cleaved beta-amyloid peptides in cells expressing mutants of the amyloid precursor protein defective in endocytosis

21 June 2018

1 reference

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Intraneuronal Abeta42 accumulation in human brain.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024135

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024135

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 June 2018

1 reference

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Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

21 June 2018

1 reference

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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

21 June 2018

1 reference

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Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains

21 June 2018

1 reference

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Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

21 June 2018

1 reference

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Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

21 June 2018

1 reference

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Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

21 June 2018

1 reference

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Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells

21 June 2018

1 reference

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Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

21 June 2018

1 reference

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 June 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 June 2018

1 reference

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 June 2018

1 reference

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Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

21 June 2018

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APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy

21 January 2018

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Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition

21 January 2018

1 reference

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A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice

21 January 2018

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Alzheimer disease risk and genetic variation in ACE: a meta-analysis

21 January 2018

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Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice.

21 January 2018

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Metabolic regulation of brain Abeta by neprilysin

21 January 2018

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alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.

21 January 2018

1 reference

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Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

21 January 2018

1 reference

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APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

21 January 2018

1 reference

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Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays

21 January 2018

1 reference

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Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

21 January 2018

1 reference

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Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

Urea-based two-dimensional electrophoresis of beta-amyloid peptides in human plasma: evidence for novel Abeta species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

21 January 2018

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Presenilin-1 mutations in Alzheimer's disease.

21 January 2018

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Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival

21 January 2018

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Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

21 January 2018

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Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

Age-dependent axonal degeneration in an Alzheimer mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-014-1287-X

Oligomeric pyroglutamate amyloid-β is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024135

Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024135

Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024135

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024135

Intraneuronal Abeta42 accumulation in Down syndrome brain

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024135

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024135

Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells

30 October 2018

1 reference

12 December 2020

Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice

1 reference

12 December 2020

Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease

1 reference

12 December 2020

Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease

1 reference

12 December 2020

Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism

1 reference

12 December 2020

The plasmin system is induced by and degrades amyloid-beta aggregates

1 reference

12 December 2020

Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity

1 reference

12 December 2020

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)

1 reference

12 December 2020

10.1007/S00401-014-1287-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803226%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803226%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

24803226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803226%20AND%20SRC:MED&resulttype=core&format=json