The role of Wnt signaling in the development of Alzheimer's disease: a potential therapeutic target? (Q33634629)

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19 March 2020

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13 November 2020

The role of Wnt signaling in the development of Alzheimer's disease: a potential therapeutic target? (English)

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19 March 2020

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13 November 2020

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13 November 2020

1

1 reference

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19 March 2020

Lumei Liu

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19 March 2020

Yaming Li

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19 March 2020

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Shijin Xia

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19 March 2020

Bill Kalionis

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4 May 2014

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25 April 2019

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19 March 2020

13 November 2020

BioMed Research International

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25 June 2019

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13 November 2020

2014

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19 March 2020

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21 June 2018

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21 June 2018

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Regulation of NMDA-receptor synaptic transmission by Wnt signaling

21 June 2018

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Curcumin activates Wnt/β-catenin signaling pathway through inhibiting the activity of GSK-3β in APPswe transfected SY5Y cells

21 June 2018

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Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model

21 June 2018

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Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice

21 June 2018

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Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide

21 June 2018

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Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses.

21 June 2018

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21 June 2018

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Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

21 June 2018

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Wnt trafficking: new insights into Wnt maturation, secretion and spreading

21 June 2018

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Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Wnt signaling in development and disease

21 June 2018

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Towards an integrated view of Wnt signaling in development

21 June 2018

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Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations.

21 June 2018

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21 June 2018

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Proximal events in Wnt signal transduction

21 June 2018

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Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons

21 June 2018

1 reference

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Wnt signaling in Alzheimer's disease: up or down, that is the question

21 June 2018

1 reference

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Wnt/beta-catenin signaling controls development of the blood-brain barrier

21 June 2018

1 reference

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Wnt signaling in neuroprotection and stem cell differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Alternative wnt signaling is initiated by distinct receptors.

21 June 2018

1 reference

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Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Wnt signaling in neural circuit assembly

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway

21 June 2018

1 reference

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Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons.

21 June 2018

1 reference

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The GSK3 hypothesis of Alzheimer's disease

21 June 2018

1 reference

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Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

21 June 2018

1 reference

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Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease

21 June 2018

1 reference

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Synaptotoxicity in Alzheimer's disease: the Wnt signaling pathway as a molecular target

21 June 2018

1 reference

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

21 June 2018

1 reference

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Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors

21 June 2018

1 reference

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Noncanonical Wnt signaling and neural polarity

21 June 2018

1 reference

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CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling

21 June 2018

1 reference

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Wnt and calcium signaling: beta-catenin-independent pathways

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

WNTs in the vertebrate nervous system: from patterning to neuronal connectivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

The Wnt signaling pathway in development and disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Pathways towards and away from Alzheimer's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Colon cancer--understanding how NSAIDs work

21 June 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

2011 Alzheimer's disease facts and figures

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Abeta exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

β-catenin is critical for dendritic morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F301575

Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026919

Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24883305

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24883305

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Canonical Wnt signalling plays essential roles

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24883305

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2014/301575

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24883305%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24883305%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24883305%20AND%20SRC:MED&resulttype=core&format=json