The role of uric acid in kidney fibrosis: experimental evidences for the causal relationship. (Q33634704)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

27 November 2020

The role of uric acid in kidney fibrosis: experimental evidences for the causal relationship (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json

chronic renal insufficiency

19 March 2020

main subject

3 references

13 March 2019

17 September 2019

29 May 2020

heterocyclic compound

1 reference

17 September 2019

1 reference

27 November 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

author name string

Il Young Kim

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Dong Won Lee

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Ihm Soo Kwak

series ordinal

4

1 reference

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19 March 2020

language of work or name

English

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publication date

5 May 2014

4 references

13 March 2019

17 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

27 November 2020

BioMed Research International

5 references

13 March 2019

17 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

29 May 2020

27 November 2020

2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

page(s)

638732

1 reference

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Creative Commons Attribution 3.0 Unported

19 March 2020

copyright license

3 references

13 March 2019

17 September 2019

on focus list of Wikimedia project

27 November 2020

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

Potential approaches to reverse or repair renal fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid and chronic kidney disease: A time to act?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

MicroRNAs in kidney fibrosis and diabetic nephropathy: roles on EMT and EndMT

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK phosphatase-1-mediated inactivation of JNK

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Allopurinol for prevention of progression of kidney disease with hyperuricemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Animal models of chronic kidney disease: useful but not perfect

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid and chronic kidney disease: which is chasing which?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid as a target of therapy in CKD.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Efficacy and safety of febuxostat in patients with hyperuricemia and gout

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

New insights into uric acid effects on the progression and prognosis of chronic kidney disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

The role of EMT in renal fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid as a cardiometabolic risk factor: to be or not to be.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Febuxostat for treatment of chronic gout

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Models of chronic kidney disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Mechanistic connection between inflammation and fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Effect of allopurinol in chronic kidney disease progression and cardiovascular risk

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

New insights into epithelial-mesenchymal transition in kidney fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

EMT: when epithelial cells decide to become mesenchymal-like cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

The role of hyperuricemia and gout in kidney and cardiovascular disease.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid: the oxidant-antioxidant paradox

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Control of renal uric acid excretion and gout

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Effects of acute and chronic L-arginine treatment in experimental hyperuricemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Pharmacokinetics and pharmacodynamics of febuxostat (TMX-67), a non-purine selective inhibitor of xanthine oxidase/xanthine dehydrogenase (NPSIXO) in patients with gout and/or hyperuricemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Epithelial-mesenchymal transition and its implications for fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Hyperuricemia and urate nephropathy in urate oxidase-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Renal handling of uric acid in normal and gouty subject: evidence for a 4-component system

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Antioxidant defenses and lipid peroxidation in human blood plasma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Uric acid as radical scavenger and antioxidant in the heart.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Challenges of conducting a trial of uric-acid-lowering therapy in CKD.

21 June 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Metabolism and excretion of [14C] febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, in healthy male subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

A role for uric acid in the progression of renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Adenine-induced chronic kidney and cardiovascular damage in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Mild hyperuricemia induces glomerular hypertension in normal rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Hyperuricemia exacerbates chronic cyclosporine nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Febuxostat contributes to improvement of endothelial dysfunction in an experimental model of streptozocin-induced diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Phosphorylation of xanthine dehydrogenase/oxidase in hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Mononuclear Phagocyte Xanthine Oxidoreductase Contributes to Cytokine-Induced Acute Lung Injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Hyperuricemia, gout, and renal function after liver transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Early treatment with allopurinol in familial juvenile hyerpuricaemic nephropathy (FJHN) ameliorates the long-term progression of renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Uric acid and chronic kidney disease: new understanding of an old problem

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026934

Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy

30 October 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F638732

Use of uric acid-lowering agents limits experimental cyclosporine nephropathy.

21 January 2018

1 reference

12 December 2020

Effect of uric acid on liver injury during hemorrhagic shock

1 reference

12 December 2020

Role of Increased Production of Superoxide Anions by NAD(P)H Oxidase and Xanthine Oxidase in Prolonged Endotoxemia

1 reference

12 December 2020

Effect of Febuxostat on the Progression of Renal Disease in 5/6 Nephrectomy Rats with and without Hyperuricemia

1 reference

12 December 2020

Requiem for gouty nephropathy

1 reference

12 December 2020

Reappraisal of the pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal disease

1 reference

12 December 2020

Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathways involving PKC, MAPK, cPLA2, and NF-κB

1 reference

12 December 2020

Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development

1 reference

12 December 2020

Febuxostat (Uloric) for chronic treatment of gout

1 reference

12 December 2020

Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents

1 reference

12 December 2020

Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions

1 reference

12 December 2020

Reducing serum uric acid attenuates TGF-β1-induced profibrogenic progression in type 2 diabetic nephropathy

1 reference

12 December 2020

Identifiers

DOI

10.1155/2014/638732

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24877124%20AND%20SRC:MED&resulttype=core&format=json