Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication (Q33649728)

28 July 2017

title

Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication (English)

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28 July 2017

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F D Goodrum

1

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28 July 2017

D A Ornelles

series ordinal

2

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28 July 2017

publication date

1 September 1999

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28 July 2017

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28 July 2017

volume

73

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28 July 2017

issue

9

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28 July 2017

page(s)

7474-7488

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describes a project that uses

28 July 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC104274/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Transforming potential of the adenovirus type 5 E4orf3 protein

14 July 2018

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Recombinant, replication-defective adenovirus gene transfer vectors induce cell cycle dysregulation and inappropriate expression of cyclin proteins.

14 July 2018

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p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection

14 July 2018

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Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells.

14 July 2018

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E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs

14 July 2018

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CRM1 is responsible for intracellular transport mediated by the nuclear export signal

14 July 2018

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CRM1 is an export receptor for leucine-rich nuclear export signals

14 July 2018

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Exportin 1 (Crm1p) is an essential nuclear export factor

14 July 2018

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The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.

14 July 2018

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Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.

14 July 2018

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The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function

14 July 2018

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The PML nuclear compartment and cancer

14 July 2018

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The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle

14 July 2018

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Oncogenic potential of the adenovirus E4orf6 protein

14 July 2018

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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

14 July 2018

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Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.

14 July 2018

1 reference

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mRNA export correlates with activation of transcription in human subgroup C adenovirus-infected cells

14 July 2018

1 reference

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Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

14 July 2018

1 reference

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Adenovirus E1A proteins inhibit activation of transcription by p53.

14 July 2018

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Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure.

14 July 2018

1 reference

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Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis

14 July 2018

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

14 July 2018

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Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

14 July 2018

1 reference

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A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

14 July 2018

1 reference

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Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs.

14 July 2018

1 reference

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Effects of mutant Ran/TC4 proteins on cell cycle progression.

14 July 2018

1 reference

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Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression

14 July 2018

1 reference

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Rearrangements of intranuclear structures involved in RNA processing in response to adenovirus infection.

14 July 2018

1 reference

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HSV-1 IE protein Vmw110 causes redistribution of PML.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Adenovirus infection induces rearrangements in the intranuclear distribution of the nuclear body-associated PML protein.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Disruption of PML-associated nuclear bodies during human cytomegalovirus infection

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

An improved T1/A ribonuclease protection assay.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Discontinuous RNA and protein synthesis and accumulation during cell cycle of Ehrlich ascites tumour cells.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Identification of two nuclear subclasses of the adenovirus type 5-encoded DNA-binding protein

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Redundant control of adenovirus late gene expression by early region 4

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Adenovirus early region 4 is essential for normal stability of late nuclear RNAs

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Dissection of functional domains in the adenovirus 2 early 1B 55K polypeptide by suppressor-linker insertional mutagenesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Interaction of adenoviral E4 and E1b products in late gene expression

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Identification of a novel nuclear domain

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Messenger RNA turnover in cell-free extracts

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: association with nuclear viral inclusions requires the early region 4 34-kilodalton protein

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Inhibition of HeLa cell protein synthesis during adenovirus infection. Restriction of cellular messenger RNA sequences to the nucleus

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Two adenovirus proteins with redundant activities in virus growth facilitates tripartite leader mRNA accumulation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0).

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Sequestration of PML and Sp100 proteins in an intranuclear viral structure during herpes simplex virus type 1 infection

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104274

Effect of adenovirus on host cell DNA synthesis in synchronized cells

30 October 2018

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12 December 2020

Isolation of deletion and substitution mutants of adenovirus type 5

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12 December 2020

Visualization of nascent RNA transcripts and simultaneous transcription and replication in viral nucleoprotein complexes from adenovirus 2-infected HeLa cells

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12 December 2020

Isolation of type 5 adenovirus mutants with a cold-sensitive host range phenotype: genetic evidence of an adenovirus transformation maintenance function

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12 December 2020

Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes

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12 December 2020

The relation between length of the cell cycle duration and RNA content in HeLa S3 cells

1 reference

12 December 2020

Analysis by in situ hybridization and autoradiography of sites of replication and storage of single- and double-stranded adenovirus type 5 DNA in lytically infected HeLa cells

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12 December 2020

The metabolism of host RNAs in cells infected by an adenovirus E4 mutant

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12 December 2020

Distribution of viral RNA molecules during the adenovirus type 5 infectious cycle in HeLa cells

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12 December 2020

Identifiers

PMC publication ID

104274

1 reference

28 July 2017

1 reference