Rapamycin extends life and health in C57BL/6 mice (Q33684583)

28 July 2017

Rapamycin extends life and health in C57BL/6 mice (English)

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28 July 2017

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16

Steven N Austad

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28 July 2017

6

Gene Hubbard

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28 July 2017

15

Arlan Richardson

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28 July 2017

Yiqiang Zhang

1

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28 July 2017

Alex Bokov

2

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28 July 2017

John Gelfond

3

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28 July 2017

Vanessa Soto

4

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28 July 2017

Yuji Ikeno

5

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28 July 2017

Vivian Diaz

7

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28 July 2017

Lauren Sloane

8

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28 July 2017

Keith Maslin

9

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28 July 2017

Stephen Treaster

10

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28 July 2017

Samantha Réndon

11

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28 July 2017

Holly van Remmen

12

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28 July 2017

Walter Ward

13

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28 July 2017

Martin Javors

14

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28 July 2017

Kathleen Fischer

17

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28 July 2017

language of work or name

English

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publication date

16 May 2013

1 reference

The Journals of Gerontology

28 July 2017

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28 July 2017

69

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28 July 2017

2

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28 July 2017

119-130

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Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

When autophagy meets cancer through p62/SQSTM1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Rapamycin slows aging in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Cardiac mTOR protects the heart against ischemia-reperfusion injury

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Combination therapy in metastatic renal cell carcinoma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Sirolimus and its analogs and its effects on vascular diseases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Can autophagy promote longevity?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Effect of low-dose rapamycin on tumor growth in two human hepatocellular cancer cell lines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Autophagy and aging: keeping that old broom working

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Novel method for high-throughput phenotyping of sleep in mice.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

TOR signaling in growth and metabolism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Extension of chronological life span in yeast by decreased TOR pathway signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Neurocognitive consequences of sleep deprivation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Current immunosuppressive agents: efficacy, side effects, and utilization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

21 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLT056

Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice: inhibitory effect on monocyte chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLT056

Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLT056

Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLT056

Determination of proteasomal activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLT056

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLT056

p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038246

Housing density does not influence the longevity effect of calorie restriction

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23682161

12 December 2020

inferred from PubMed ID database lookup

Step length reductions in advanced age: the role of ankle and hip kinetics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23682161

12 December 2020

inferred from PubMed ID database lookup

Rapamycin as immunosuppressant in murine transplantation model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23682161

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/GERONA/GLT056

1 reference

release_lsagjqsvpbhnbfkqph33w3sbei

28 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lsagjqsvpbhnbfkqph33w3sbei

24 November 2022

mapped directly with Wikidata item

PMCID

4038246

1 reference

28 July 2017

1 reference