Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha (Q33690338)

28 July 2017

Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha (English)

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28 July 2017

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E C Merkhofer

1

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28 July 2017

P Cogswell

series ordinal

2

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28 July 2017

A S Baldwin

series ordinal

3

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28 July 2017

language of work or name

English

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publication date

30 November 2009

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28 July 2017

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28 July 2017

29

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28 July 2017

8

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28 July 2017

1238-1248

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https://scigraph.springernature.com/pub.10.1038/onc.2009.410

28 July 2017

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Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

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Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion

21 June 2018

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PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesis

21 June 2018

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21 June 2018

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IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells

21 June 2018

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Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer

21 June 2018

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Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription

21 June 2018

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Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

21 June 2018

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21 June 2018

Signaling to NF-kappaB

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NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis

21 June 2018

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

21 June 2018

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Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway

21 June 2018

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Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance

21 June 2018

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Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway

21 June 2018

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Missing pieces in the NF-kappaB puzzle

21 June 2018

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Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

21 June 2018

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

21 June 2018

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The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome

21 June 2018

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Cytokines facilitate chemotactic motility of breast carcinoma cells

21 June 2018

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Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors

21 June 2018

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IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

21 June 2018

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Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

21 June 2018

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Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment

21 June 2018

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Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

21 June 2018

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Oncogenic Neu/ErbB-2 increases ets, AP-1, and NF-kappaB-dependent gene expression, and inhibiting ets activation blocks Neu-mediated cellular transformation

21 June 2018

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Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media

21 June 2018

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The biology of erbB-2/neu/HER-2 and its role in cancer

21 June 2018

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Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene.

21 June 2018

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

21 June 2018

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

21 June 2018

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829103

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

21 June 2018

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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.410

Her-2/neu-induced "cytokine signature" in breast cancer.

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829103

NIK is a component of the EGF/heregulin receptor signaling complexes

30 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.410

Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.410

Phase II study of weekly intravenous trastuzumab (Herceptin) in patients with HER2/neu-overexpressing metastatic breast cancer

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19946332

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2009.410

1 reference

Dimensions Publication ID

28 July 2017

0 references

1 reference

28 July 2017

1 reference