Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sites (Q33714571)

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English	Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sites	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

28 July 2017

Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sites (English)

1 reference

Europe PubMed Central

28 July 2017

author name string

Jin Zhou

1

1 reference

Europe PubMed Central

28 July 2017

Timothy S Tracy

2

1 reference

Europe PubMed Central

28 July 2017

Rory P Remmel

3

1 reference

Europe PubMed Central

28 July 2017

publication date

9 December 2009

1 reference

Europe PubMed Central

28 July 2017

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

28 July 2017

38

1 reference

Europe PubMed Central

28 July 2017

3

1 reference

Europe PubMed Central

28 July 2017

431-440

1 reference

Europe PubMed Central

28 July 2017

In vitro and in vivo glucuronidation of midazolam in humans

1 reference

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Identification of UDP glycosyltransferase 3A1 as a UDP N-acetylglucosaminyltransferase.

1 reference

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Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by udp-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites

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Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties

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21 June 2018

Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation

1 reference

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CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds

1 reference

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Product inhibition of UDP-glucuronosyltransferase (UGT) enzymes by UDP obfuscates the inhibitory effects of UGT substrates.

1 reference

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Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7

1 reference

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Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

1 reference

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Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants

1 reference

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In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction

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In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises

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Inactivation of the pure antiestrogen fulvestrant and other synthetic estrogen molecules by UDP-glucuronosyltransferase 1A enzymes expressed in breast tissue

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UDP-glucuronosyltransferases and clinical drug-drug interactions

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Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches.

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Inhibition and active sites of UDP-glucuronosyltransferases 2B7 and 1A1.

1 reference

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Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.

1 reference

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A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.

1 reference

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Human UDP-glucuronosyltransferases: metabolism, expression, and disease

1 reference

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In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model

1 reference

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Structural and functional studies of UDP-glucuronosyltransferases

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The "albumin effect" and in vitro-in vivo extrapolation: sequestration of long-chain unsaturated fatty acids enhances phenytoin hydroxylation by human liver microsomal and recombinant cytochrome P450 2C9.

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Resveratrol (trans-resveratrol, 3,5,4'-trihydroxy-trans-stilbene) glucuronidation exhibits atypical enzyme kinetics in various protein sources

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Isoflavones modulate the glucuronidation of estradiol in human liver microsomes

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Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases.

1 reference

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Effects of beta-estradiol and propofol on the 4-methylumbelliferone glucuronidation in recombinant human UGT isozymes 1A1, 1A8 and 1A9.

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Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4.

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Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid

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Substrate inhibition kinetics for cytochrome P450-catalyzed reactions

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Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

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1 reference

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Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20007295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/20007295

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Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement

1 reference

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Identifiers

10.1124/DMD.109.028712

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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