TPL2 kinase regulates the inflammatory milieu of the myeloma niche (Q33714724)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24723682%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

TPL2 kinase regulates the inflammatory milieu of the myeloma niche (English)

1 reference

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13 March 2020

6

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13 March 2020

Natalie Callander

11

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13 March 2020

author name string

Chelsea Hope

1

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13 March 2020

Samuel J Ollar

2

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13 March 2020

Erika Heninger

3

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13 March 2020

Ellen Hebron

4

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13 March 2020

Jeffrey L Jensen

5

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13 March 2020

Ioanna Maroulakou

7

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13 March 2020

Shigeki Miyamoto

8

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13 March 2020

Catherine Leith

9

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13 March 2020

David T Yang

10

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13 March 2020

Peiman Hematti

12

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13 March 2020

Marta Chesi

13

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13 March 2020

P Leif Bergsagel

14

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13 March 2020

Fotis Asimakopoulos

15

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13 March 2020

language of work or name

English

0 references

publication date

10 April 2014

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13 March 2020

1 reference

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13 March 2020

volume

123

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13 March 2020

issue

21

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13 March 2020

page(s)

3305-3315

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Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

13 March 2020

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Tpl2 inhibitors thwart endothelial cell function in angiogenesis and peritoneal dissemination

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Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma.

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Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms

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Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts

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21 June 2018

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TPL2 kinase is a suppressor of lung carcinogenesis

21 June 2018

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Roles of versican in cancer biology--tumorigenesis, progression and metastasis

21 June 2018

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Macrophages in multiple myeloma: emerging concepts and therapeutic implications

21 June 2018

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Tumor-produced versican V1 enhances hCAP18/LL-37 expression in macrophages through activation of TLR2 and vitamin D3 signaling to promote ovarian cancer progression in vitro

21 June 2018

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Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients

21 June 2018

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MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages

21 June 2018

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Bone marrow microenvironment in multiple myeloma progression.

21 June 2018

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Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.

21 June 2018

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Microenvironmental regulation of epithelial-mesenchymal transitions in cancer

21 June 2018

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Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages

21 June 2018

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Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells

21 June 2018

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Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

21 June 2018

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21 June 2018

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21 June 2018

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Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.

21 June 2018

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Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

21 June 2018

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RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration

21 June 2018

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Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition

21 June 2018

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Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

21 June 2018

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21 June 2018

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The ADAMTS1 protease gene is required for mammary tumor growth and metastasis

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

21 June 2018

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Gene expression profile of ADAMs and ADAMTSs metalloproteinases in normal and malignant plasma cells and in the bone marrow environment.

21 June 2018

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HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

21 June 2018

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Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

21 June 2018

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

21 June 2018

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Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).

21 June 2018

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Versican G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing EGF receptor signaling

21 June 2018

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Use of tissue microarray and automated quantitative analysis for screening and validation of potential biomarkers in mantle cell lymphoma

21 June 2018

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ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice

21 June 2018

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Post-transcriptional regulons coordinate the initiation and resolution of inflammation

21 June 2018

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Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.

21 June 2018

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ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

21 June 2018

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Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages

21 June 2018

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Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis

21 June 2018

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Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

21 June 2018

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Immunological and inflammatory functions of the interleukin-1 family

21 June 2018

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The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules

21 June 2018

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Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1{beta}-induced interleukin 6 production and the myeloma proliferative component

21 June 2018

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Regulation of macrophage function in tumors: the multifaceted role of NF-kappaB.

21 June 2018

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The biological role and regulation of versican levels in cancer.

21 June 2018

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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

21 June 2018

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Pattern recognition receptors and control of adaptive immunity

21 June 2018

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"Re-educating" tumor-associated macrophages by targeting NF-kappaB.

21 June 2018

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Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms

21 June 2018

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The role of the bone marrow microenvironment in the pathophysiology of myeloma and its significance in the development of more effective therapies

21 June 2018

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Identification of two groups of smoldering multiple myeloma patients who are either high or low producers of interleukin-1.

21 June 2018

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The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma

21 June 2018

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

21 June 2018

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Survival and proliferation factors of normal and malignant plasma cells

21 June 2018

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A review of the cytokine network in multiple myeloma: diagnostic, prognostic, and therapeutic implications

21 June 2018

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21 June 2018

IL-10 in myeloma cells

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Multiple myeloma: evolving genetic events and host interactions

21 June 2018

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Toll-like receptors and innate immunity

21 June 2018

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

21 June 2018

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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

21 June 2018

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The role of interleukin-1 beta in the pathogenesis of multiple myeloma

21 June 2018

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Interleukin-10 and Gp130 cytokines in human multiple myeloma

21 June 2018

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Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.

21 June 2018

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Pro-inflammatory cytokines and the pathogenesis of Gaucher's disease: increased release of interleukin-6 and interleukin-10.

21 June 2018

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Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

B cell lymphoma and myeloma in murine Gaucher's disease.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

Involvement of Cot activity in the proliferation of ALCL lymphoma cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

Regulators of macrophage activation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

Evidence for a proinflammatory and proteolytic environment in plaques from endarterectomy segments of human carotid arteries

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

Role of cytokines in multiple myeloma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046426

Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells

30 October 2018

1 reference

12 December 2020

Interleukin-1 in multiple myeloma: producer cells and their role in the control of IL-6 production

1 reference

12 December 2020

Interleukin-6 is a prognostic factor in multiple myeloma

1 reference

12 December 2020

The role of monocytes-macrophages in vasculogenesis in multiple myeloma

1 reference

12 December 2020

Treatment of multiple myeloma

1 reference

12 December 2020

Regulation of Toll-like receptors in human monocytes and dendritic cells

1 reference

12 December 2020

Macrophages as an important source of paracrine IL6 in myeloma bone marrow

1 reference

12 December 2020

10.1182/BLOOD-2014-02-554071

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24723682%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24723682%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24723682%20AND%20SRC:MED&resulttype=core&format=json