Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression. (Q54598471)

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English	Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression. (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

toll-like receptor

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author name string

Marta López-Peláez

1

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

Irene Soria-Castro

2

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

Lisardo Boscá

3

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

Margarita Fernández

4

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

Susana Alemany

5

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

language of work or name

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publication date

24 May 2011

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

European Journal of Immunology

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

41

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

6

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Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

1733-1741

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

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Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

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The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells

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PI3K and negative regulation of TLR signaling.

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The multiple facets of mTOR in immunity.

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The TSC-mTOR signaling pathway regulates the innate inflammatory response

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TLR4/MyD88/PI3K interactions regulate TLR4 signaling

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Toll-like receptor signalling

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NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

1 reference

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Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis

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SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase

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Regulation and function of NF-kappaB transcription factors in the immune system

1 reference

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TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

1 reference

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21 January 2018

IkappaB kinase is an essential component of the Tpl2 signaling pathway

1 reference

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21 January 2018

NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

1 reference

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21 January 2018

ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability

1 reference

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21 January 2018

ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

1 reference

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21 January 2018

ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling

1 reference

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21 January 2018

Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.

1 reference

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21 January 2018

Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide

1 reference

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21 January 2018

Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages

1 reference

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21 January 2018

IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.

1 reference

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21 January 2018

NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity

1 reference

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21 January 2018

Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041101

21 January 2018

The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity

1 reference

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Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells

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21 January 2018

Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.

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21 January 2018

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

1 reference

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21 January 2018

15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide.

1 reference

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21 January 2018

Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

1 reference

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21 January 2018

TRAF6 and Src kinase activity regulates Cot activation by IL-1.

1 reference

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21 January 2018

Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041101

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Cot/tpl2 (MAP3K8) Mediates Myeloperoxidase Activity and Hypernociception following Peripheral Inflammation*

1 reference

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21 January 2018

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages

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iNOS (NOS2) at a glance

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The IRF family transcription factors in immunity and oncogenesis

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TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells

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A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.

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Identification and functional characterization of a second chain of the interleukin-10 receptor complex

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The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs

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An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation

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Selective activation of liver X receptors by acanthoic acid-related diterpenes.

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COX2 expression and Erk1/Erk2 activity mediate Cot-induced cell migration

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7 January 2021

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Identifiers

10.1002/EJI.201041101

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21469113

ResearchGate publication ID

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