Chemical inhibitors of cyclin-dependent kinases: insights into design from X-ray crystallographic studies. (Q33716140)

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11 December 2019

review article

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title

Chemical inhibitors of cyclin-dependent kinases: insights into design from X-ray crystallographic studies (English)

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11 December 2019

1

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11 December 2019

author name string

J A Endicott

series ordinal

2

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11 December 2019

publication date

1 May 1999

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Pharmacology & Therapeutics

11 December 2019

published in

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11 December 2019

volume

82

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11 December 2019

issue

2-3

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11 December 2019

page(s)

269-278

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CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation

11 December 2019

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Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

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Crystal structure of cyclin-dependent kinase 2

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Cdk inhibitors: on the threshold of checkpoints and development

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Modelling study of protein kinase inhibitors: binding mode of staurosporine and origin of the selectivity of CGP 52411

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Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions

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K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

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Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

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Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases

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Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2

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Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

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Cyclin-dependent kinases: engines, clocks, and microprocessors

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A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). I. Screening, taxonomy, fermentation and biological activity.

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When checkpoints fail

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7 January 2021

High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

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Identifiers

DOI

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11 December 2019

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