CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia (Q33728096)

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English	CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia	scientific article

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21 March 2020

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia (English)

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21 March 2020

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21 March 2020

Patricia Martín-Rodíguez

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21 March 2020

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21 March 2020

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21 March 2020

Francisco G Rodriguez Gonzalez

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21 March 2020

Ana Estévez-Braun

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21 March 2020

Atanasio Pandiella

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Atanasio Pandiella

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21 March 2020

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Juan Carlos Díaz-Chico

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21 March 2020

Grant McNaughton-Smith

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21 March 2020

Sandra Jiménez-Alonso

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21 March 2020

Idaira Hueso-Falcón

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21 March 2020

Bonifacio Nicolás Díaz-Chico

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21 March 2020

Leandro Fernández-Pérez

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21 March 2020

Rosa Blanco

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21 March 2020

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1 May 2017

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21 March 2020

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21 March 2020

8

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21 March 2020

18

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21 March 2020

29679-29698

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21 March 2020

Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms.

1 reference

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Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia

1 reference

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1 reference

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JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.

1 reference

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14 July 2018

NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.

1 reference

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14 July 2018

Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.

1 reference

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14 July 2018

MCL-1 degradation mediated by JNK activation via MEKK1/TAK1-MKK4 contributes to anticancer activity of new tubulin inhibitor MT189.

1 reference

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14 July 2018

JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia

1 reference

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14 July 2018

Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT)

1 reference

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14 July 2018

Inhibition of related JAK/STAT pathways with molecular targeted drugs shows strong synergy with ruxolitinib in chronic myeloproliferative neoplasm

1 reference

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14 July 2018

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14 July 2018

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia

1 reference

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14 July 2018

The chemical biology of naphthoquinones and its environmental implications

1 reference

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14 July 2018

Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression

1 reference

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14 July 2018

MYC in chronic myeloid leukemia: induction of aberrant DNA synthesis and association with poor response to imatinib.

1 reference

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14 July 2018

Janus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia

1 reference

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14 July 2018

Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

1 reference

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14 July 2018

LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells

1 reference

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14 July 2018

Drug combination studies and their synergy quantification using the Chou-Talalay method

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14 July 2018

New insights into checkpoint kinase 1 in the DNA damage response signaling network

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14 July 2018

Imatinib and beyond--exploring the full potential of targeted therapy for CML.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444695

14 July 2018

ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444695

14 July 2018

Mechanisms of primary and secondary resistance to imatinib in chronic myeloid leukemia

1 reference

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14 July 2018

CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients

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DNA damage signalling guards against activated oncogenes and tumour progression

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Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia

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Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

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Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines

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1 reference

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30 October 2018

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1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies with a growth hormone antagonist and dual-fluorescent confocal microscopy demonstrate that the full-length human growth hormone receptor, but not the truncated isoform, is very rapidly internalized independent of Jak2-Stat5 signaling

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

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Positively charged polymer polylysine-induced cell adhesion molecule redistribution in K562 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27557509

12 December 2020

based on heuristic

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Identifiers

10.18632/ONCOTARGET.11425

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21 March 2020

PMC publication ID

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21 March 2020

PubMed publication ID

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21 March 2020

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