No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro (Q33733724)

29 July 2017

No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro (English)

1 reference

29 July 2017

1 reference

Dylan W Peterson

1

1 reference

29 July 2017

D Michael Ando

2

1 reference

29 July 2017

Daryl A Taketa

3

1 reference

29 July 2017

Hongjun Zhou

4

1 reference

29 July 2017

Fredrick W Dahlquist

5

1 reference

29 July 2017

John Lew

6

1 reference

29 July 2017

language of work or name

English

0 references

publication date

1 February 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

1 reference

29 July 2017

107

1 reference

29 July 2017

7

1 reference

29 July 2017

2884-2889

1 reference

Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

A soluble oligomer of tau associated with fiber formation analyzed by NMR.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

MAP kinases and CDKs: kinetic basis for catalytic activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Cdk5 phosphorylates p53 and regulates its activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Neurotoxicity induces cleavage of p35 to p25 by calpain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Catalytic reaction pathway for the mitogen-activated protein kinase ERK2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Possible role of tau protein kinases in pathogenesis of Alzheimer's disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Neuronal cdc2-like kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Purification and characterization of a novel proline-directed protein kinase from bovine brain.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain.

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

A brain-specific activator of cyclin-dependent kinase 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Precursor of cdk5 activator, the 23 kDa subunit of tau protein kinase II: its sequence and developmental change in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Substrate specificity of CDK2-cyclin A. What is optimal?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Controversies over p25 in Alzheimer's disease.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840295

Neurobiology: p25 protein in neurodegeneration

30 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912718107

Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25

21 January 2018

1 reference

12 December 2020

Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain

1 reference

12 December 2020

In vivo phosphorylation sites in fetal and adult rat tau

1 reference

12 December 2020

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

1 reference

12 December 2020

Analysis of phosphorylation of tau with antibodies specific for phosphorylation sites

1 reference

12 December 2020

Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0912718107

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference