Gated access to the pore of a P2X receptor: structural implications for closed-open transitions. (Q33744436)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20093367%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Gated access to the pore of a P2X receptor: structural implications for closed-open transitions (English)

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17 January 2020

2

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17 January 2020

author name string

Sebastian Kracun

series ordinal

1

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17 January 2020

Jeff Abramson

series ordinal

3

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17 January 2020

Baljit S Khakh

series ordinal

4

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17 January 2020

language of work or name

English

0 references

publication date

21 January 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20093367%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

17 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20093367%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

285

1 reference

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17 January 2020

issue

13

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17 January 2020

page(s)

10110-10121

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20093367%20AND%20SRC:MED&resulttype=core&format=json

Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectification

17 January 2020

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Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

21 June 2018

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Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

21 June 2018

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Direct observation of ATP-induced conformational changes in single P2X(4) receptors

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Opposite effects of zinc on human and rat P2X2 receptors.

21 June 2018

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Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels

21 June 2018

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Gating the pore of P2X receptor channels

21 June 2018

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Permeation properties of a P2X receptor in the green algae Ostreococcus tauri

21 June 2018

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Orthosteric and allosteric binding sites of P2X receptors

21 June 2018

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Tracking transmitter-gated P2X cation channel activation in vitro and in vivo

21 June 2018

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On the role of the first transmembrane domain in cation permeability and flux of the ATP-gated P2X2 receptor

21 June 2018

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Thr339-to-serine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308.

21 June 2018

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Cadmium trapping in an epithelial sodium channel pore mutant

21 June 2018

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An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum

21 June 2018

1 reference

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A histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding site

21 June 2018

1 reference

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Physiology and pathophysiology of purinergic neurotransmission

21 June 2018

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P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate

21 June 2018

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P2X receptors as cell-surface ATP sensors in health and disease

21 June 2018

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Biophysics of P2X receptors

21 June 2018

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An intersubunit zinc binding site in rat P2X2 receptors

21 June 2018

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Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize

21 June 2018

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Coot: model-building tools for molecular graphics

21 June 2018

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Refinement of macromolecular structures by the maximum-likelihood method

21 June 2018

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Cys-loop receptors: new twists and turns

21 June 2018

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Identification of a trafficking motif involved in the stabilization and polarization of P2X receptors

21 June 2018

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Contribution of calcium ions to P2X channel responses.

21 June 2018

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Subunit Arrangement in P2X Receptors

21 June 2018

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Molecular physiology of P2X receptors

21 June 2018

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Control of P2X(2) channel permeability by the cytosolic domain

21 June 2018

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EPR approaches to ion channel structure and function

21 June 2018

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Mutational analysis of the conserved cysteines of the rat P2X2 purinoceptor.

21 June 2018

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The alpha-helix and the organization and gating of channels

21 June 2018

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Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843173

On the contribution of the first transmembrane domain to whole-cell current through an ATP-gated ionotropic P2X receptor.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843173

Polar residues of the second transmembrane domain influence cation permeability of the ATP-gated P2X(2) receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843173

Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843173

Molecular physiology of P2X receptors and ATP signalling at synapses

21 June 2018

1 reference

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The Croonian Lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission

21 June 2018

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Ion permeation and block of P2X(2) purinoceptors: single channel recordings

21 June 2018

1 reference

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Dynamic selectivity filters in ion channels

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843173

Allosteric control of gating and kinetics at P2X(4) receptor channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843173

Single channel properties of P2X2 purinoceptors

21 June 2018

1 reference

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Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.

21 June 2018

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Pore dilation of neuronal P2X receptor channels

21 June 2018

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Identification of a site that modifies desensitization of P2X2 receptors.

21 June 2018

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N-Linked glycosylation is essential for the functional expression of the recombinant P2X2 receptor

21 June 2018

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Membrane topology of an ATP-gated ion channel (P2X receptor).

21 June 2018

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P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels

21 June 2018

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Topological analysis of the ATP-gated ionotropic [correction of ionotrophic] P2X2 receptor subunit

21 June 2018

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Identification of amino acid residues contributing to the pore of a P2X receptor

21 June 2018

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P2X receptors: a third major class of ligand-gated ion channels.

21 June 2018

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Comparative protein modelling by satisfaction of spatial restraints

21 June 2018

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Pore loops: an emerging theme in ion channel structure

21 June 2018

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New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

21 June 2018

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A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

21 June 2018

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Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

21 June 2018

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The first transmembrane domain of the P2X receptor subunit participates in the agonist-induced gating of the channel

21 June 2018

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The role of histidine residues in modulation of the rat P2X(2) purinoceptor by zinc and pH.

21 January 2018

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Comparative models of P2X2 receptor support inter-subunit ATP-binding sites

21 January 2018

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Preservation and staining of myelinated nerve fibers.

21 January 2018

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Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]-dependent gating.

21 January 2018

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Intracellular thiol-mediated modulation of epithelial sodium channel activity

21 January 2018

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Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels

21 January 2018

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Metals in proteins: correlation between the metal-ion type, coordination number and the amino-acid residues involved in the coordination.

21 January 2018

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Functional characterization of a P2X receptor from Schistosoma mansoni

21 January 2018

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Contribution of individual subunits to the multimeric P2X(2) receptor: estimates based on methanethiosulfonate block at T336C.

21 January 2018

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Gated access to the pore of a voltage-dependent K+ channel

30 October 2018

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12 December 2020

Substituted-cysteine accessibility method

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12 December 2020

Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells

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12 December 2020

Identification of a domain involved in ATP-gated ionotropic receptor subunit assembly

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12 December 2020

A domain contributing to the ion channel of ATP-gated P2X2 receptors identified by the substituted cysteine accessibility method

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12 December 2020

Identifiers

DOI

10.1074/JBC.M109.089185

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20093367%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20093367%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

20093367

1 reference