Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. (Q33754831)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20064975%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20064975%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

main subject

Drosophila melanogaster

0 references

1 reference

1

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16 January 2020

author name string

W Gregory Alvord

series ordinal

2

1 reference

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16 January 2020

Octavio A Quiñones

series ordinal

3

1 reference

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16 January 2020

Mark E Fortini

series ordinal

4

1 reference

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16 January 2020

publication date

11 January 2010

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16 January 2020

published in

Molecular Pharmacology

1 reference

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16 January 2020

volume

77

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16 January 2020

issue

4

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16 January 2020

page(s)

567-574

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20064975%20AND%20SRC:MED&resulttype=core&format=json

The canonical Notch signaling pathway: unfolding the activation mechanism

16 January 2020

cites work

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gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

21 June 2018

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21 June 2018

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Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity

21 June 2018

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Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function

21 June 2018

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Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes

21 June 2018

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Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein

21 June 2018

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Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.

21 June 2018

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Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

21 June 2018

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Presenilin: running with scissors in the membrane

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Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies

21 June 2018

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Presenilin-dependent intramembrane cleavage of ephrin-B1.

21 June 2018

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Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain

21 June 2018

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 June 2018

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Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

21 June 2018

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Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

21 June 2018

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Identification of distinct gamma-secretase complexes with different APH-1 variants

21 June 2018

1 reference

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The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

21 June 2018

1 reference

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A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

21 June 2018

1 reference

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Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 June 2018

1 reference

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Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

21 June 2018

1 reference

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The role of presenilin cofactors in the gamma-secretase complex

21 June 2018

1 reference

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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 June 2018

1 reference

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Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

21 June 2018

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Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1.

21 June 2018

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Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

21 June 2018

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Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 June 2018

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What the evolution of the amyloid protein precursor supergene family tells us about its function

21 June 2018

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Calcium depletion dissociates and activates heterodimeric notch receptors

21 June 2018

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A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.

21 June 2018

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(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor

30 October 2018

1 reference

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The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.

30 October 2018

1 reference

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Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

30 October 2018

1 reference

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Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

30 October 2018

1 reference

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Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages

30 October 2018

1 reference

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Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

30 October 2018

1 reference

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Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

30 October 2018

1 reference

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Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

30 October 2018

1 reference

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C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

10 December 2018

1 reference

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Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans

10 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20064975

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20064975

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.109.062471

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20064975%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20064975%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference