Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance (Q33755338)

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English	Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance	scientific article

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19 January 2020

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance (English)

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19 January 2020

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lymphoblastic leukemia

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glucocorticoid resistance

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Beat C Bornhauser

2

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19 January 2020

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19 January 2020

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19 January 2020

Jean-Pierre Bourquin

10

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19 January 2020

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Laura Bonapace

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19 January 2020

Maike Schmitz

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19 January 2020

Gunnar Cario

4

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19 January 2020

Urs Ziegler

5

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19 January 2020

Martin Schrappe

8

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19 January 2020

Martin Stanulla

9

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19 January 2020

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1 April 2010

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19 January 2020

Journal of Clinical Investigation

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19 January 2020

120

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19 January 2020

1310-1323

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19 January 2020

4

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19 January 2020

Autophagy, not apoptosis, is essential for midgut cell death in Drosophila

1 reference

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21 June 2018

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

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21 June 2018

RIP kinases at the crossroads of cell death and survival

1 reference

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21 June 2018

Methods to analyze cellular necroptosis

1 reference

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Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

1 reference

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Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

1 reference

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21 June 2018

Autophagic cell death: the story of a misnomer

1 reference

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FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

1 reference

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Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia

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Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

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Identification of RIP1 kinase as a specific cellular target of necrostatins

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21 June 2018

Autophagy in the Pathogenesis of Disease

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Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

1 reference

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

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21 June 2018

Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway.

1 reference

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21 June 2018

Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia.

1 reference

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21 June 2018

Atg5 and Bcl-2 provide novel insights into the interplay between apoptosis and autophagy

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21 June 2018

Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase

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21 June 2018

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

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21 June 2018

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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21 June 2018

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

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21 June 2018

Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.

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21 June 2018

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

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21 June 2018

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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21 June 2018

Glucocorticoid-induced glucocorticoid-receptor expression and promoter usage is not linked to glucocorticoid resistance in childhood ALL.

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21 June 2018

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

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21 June 2018

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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21 June 2018

Treatment of acute lymphoblastic leukemia

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Growing roles for the mTOR pathway

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21 June 2018

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

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21 June 2018

The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expression

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Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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Dexamethasone-induced Gene 2 (dig2) Is a Novel Pro-survival Stress Gene Induced Rapidly by Diverse Apoptotic Signals

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30 October 2018

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inferred from PubMed ID database lookup

Necroptosis: a specialized pathway of programmed necrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200450

12 December 2020

based on heuristic

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Identifiers

10.1172/JCI39987

1 reference

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19 January 2020

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19 January 2020

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19 January 2020

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