Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status (Q35534198)

8 August 2017

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status (English)

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8 August 2017

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2

M Foretz

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8 August 2017

B Guigas

8

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Benoit Viollet

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B Viollet

7

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Etienne Sokal

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E Sokal

5

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author name string

X Stephenne

1

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8 August 2017

N Taleux

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8 August 2017

G C van der Zon

4

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8 August 2017

L Hue

6

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8 August 2017

23 September 2011

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8 August 2017

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8 August 2017

54

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8 August 2017

3101-3110

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8 August 2017

12

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https://scigraph.springernature.com/pub.10.1007/s00125-011-2311-5

8 August 2017

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Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

12 July 2018

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

12 July 2018

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Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

12 July 2018

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Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function

12 July 2018

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Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

12 July 2018

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Mammalian complex I: a regulable and vulnerable pacemaker in mitochondrial respiratory function

12 July 2018

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

12 July 2018

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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

12 July 2018

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Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase

12 July 2018

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Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration

12 July 2018

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Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

12 July 2018

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AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside

12 July 2018

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Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review

12 July 2018

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

12 July 2018

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Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents

12 July 2018

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Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process

12 July 2018

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Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study

12 July 2018

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Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle

12 July 2018

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The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

12 July 2018

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Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

12 July 2018

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The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

12 July 2018

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Role of AMP-activated protein kinase in mechanism of metformin action

12 July 2018

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

12 July 2018

1 reference

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Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

12 July 2018

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

12 July 2018

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

12 July 2018

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AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

12 July 2018

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Metformin kinetics in healthy subjects and in patients with diabetes mellitus

12 July 2018

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High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study

12 July 2018

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Subcellular distribution of metformin in rat liver

12 July 2018

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AMPK is a direct adenylate charge-regulated protein kinase.

12 July 2018

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Increased expression of hepatic organic cation transporter 1 and hepatic distribution of metformin in high-fat diet-induced obese mice

26 September 2018

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Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice

26 September 2018

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Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

26 September 2018

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Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210354

The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210354

5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210354

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210354

Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210354

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00125-011-2311-5

Measurement of the renal clearance of drugs

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00125-011-2311-5

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00125-011-2311-5

Intracellular compartmentation and control of alanine metabolism in rat liver parenchymal cells

21 January 2018

1 reference

12 December 2020

Accumulation of metformin by tissues of the normal and diabetic mouse

1 reference

12 December 2020

Neither LKB1 nor AMPK are the direct targets of metformin

1 reference

12 December 2020

Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle

1 reference

12 December 2020

Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway

1 reference

12 December 2020

The blooming of the French lilac

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1172/JCI14178

Identifiers

DOI

10.1007/S00125-011-2311-5

1 reference

8 August 2017

1 reference

8 August 2017

1 reference