IL-4 signaling drives a unique arginase+/IL-1β+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury (Q33801629)

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English	IL-4 signaling drives a unique arginase+/IL-1β+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury	scientific article

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Europe PubMed Central

29 July 2017

IL-4 signaling drives a unique arginase+/IL-1β+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury (English)

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Europe PubMed Central

29 July 2017

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author name string

Ashley M Fenn

1

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Europe PubMed Central

29 July 2017

Jodie C E Hall

2

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Europe PubMed Central

29 July 2017

John C Gensel

3

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Europe PubMed Central

29 July 2017

Phillip G Popovich

4

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Europe PubMed Central

29 July 2017

Jonathan P Godbout

5

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29 July 2017

language of work or name

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publication date

1 June 2014

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29 July 2017

Journal of Neuroscience

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29 July 2017

34

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29 July 2017

8904-8917

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29 July 2017

26

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29 July 2017

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4069360/fullTextXML

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TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

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Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury.

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Aging enhances classical activation but mitigates alternative activation in the central nervous system

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Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

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Macrophages promote axon regeneration with concurrent neurotoxicity

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Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury.

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IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis.

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Mortality rates in geriatric patients with spinal cord injuries

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Detrimental effects of aging on outcome from traumatic brain injury: a behavioral, magnetic resonance imaging, and histological study in mice

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Traumatic spinal cord injury produced by controlled contusion in mouse

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Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures

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Rats and mice exhibit distinct inflammatory reactions after spinal cord injury

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Locomotor recovery and mechanical hyperalgesia following spinal cord injury depend on age at time of injury in rat

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Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats

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Identifiers

10.1523/JNEUROSCI.1146-14.2014

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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