A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo. (Q33812525)

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English	A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24967665%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24967665%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

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21 March 2020

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Nuruddeen D Lewis

1

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21 March 2020

Lori A Patnaude

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21 March 2020

Josephine Pelletier

3

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21 March 2020

Donald J Souza

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21 March 2020

Susan M Lukas

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21 March 2020

Jonathan D Hill

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21 March 2020

Dimitria E Stefanopoulos

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21 March 2020

Kelli Ryan

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21 March 2020

Sudha Desai

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21 March 2020

Donna Skow

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21 March 2020

Stefan G Kauschke

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21 March 2020

Andre Broermann

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21 March 2020

Daniel Kuzmich

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21 March 2020

Christian Harcken

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21 March 2020

Eugene R Hickey

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21 March 2020

Louise K Modis

17

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21 March 2020

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26 June 2014

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21 March 2020

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21 March 2020

9

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21 March 2020

6

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21 March 2020

e100883

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21 March 2020

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Creative Commons Attribution 4.0 International

26 June 2014

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LIMMA

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Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/4072711

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CZ Software Mentions: A large dataset of software mentions in the biomedical literature

Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

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4 July 2018

The kinetics of myelin antigen uptake by myeloid cells in the central nervous system during experimental autoimmune encephalomyelitis

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4 July 2018

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

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4 July 2018

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

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4 July 2018

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

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4 July 2018

Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease.

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4 July 2018

Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3.

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4 July 2018

Patented TGR5 modulators: a review (2006 - present).

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4 July 2018

Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling

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4 July 2018

TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

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4 July 2018

The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis

1 reference

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4 July 2018

The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice

1 reference

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4 July 2018

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

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4 July 2018

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease.

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4 July 2018

Expression and function of the bile acid receptor TGR5 in Kupffer cells

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).

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Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis

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G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism.

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Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells.

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30 October 2018

Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway.

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CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

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Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation.

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Identifiers

10.1371/JOURNAL.PONE.0100883

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21 March 2020

2014PLoSO...9j0883L

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21 March 2020

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21 March 2020

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