New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions (Q36184396)

12 August 2017

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title

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions (English)

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12 August 2017

interleukin-27 complex

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0070744

interleukin-23 complex

1 reference

Gene Ontology release 2020-05-02

Christopher A Hunter

1

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12 August 2017

1 July 2005

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Nature Reviews Immunology

12 August 2017

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12 August 2017

5

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12 August 2017

521-531

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12 August 2017

7

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

12 August 2017

1 reference

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

21 January 2018

1 reference

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

21 January 2018

1 reference

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist

21 January 2018

1 reference

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts

21 January 2018

1 reference

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

21 January 2018

1 reference

21 January 2018

IL-12 in autoimmunity.

1 reference

Further checkpoints in Th1 development

21 January 2018

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The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses

21 January 2018

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The lineage decisions of helper T cells

21 January 2018

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Molecular phylogeny within type I cytokines and their cognate receptors

21 January 2018

1 reference

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

21 January 2018

1 reference

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

21 January 2018

1 reference

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

1 reference

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

21 January 2018

1 reference

Cloning and characterization of a novel class I cytokine receptor

21 January 2018

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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

21 January 2018

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WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

21 January 2018

1 reference

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

21 January 2018

1 reference

Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications

21 January 2018

1 reference

A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5

21 January 2018

1 reference

Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

21 January 2018

1 reference

EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation.

21 January 2018

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Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development

21 January 2018

1 reference

Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

21 January 2018

1 reference

Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

21 January 2018

1 reference

Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40.

21 January 2018

1 reference

IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity

21 January 2018

1 reference

Interleukin-12 and the regulation of innate resistance and adaptive immunity

21 January 2018

1 reference

Recombinant interleukin 12 cures mice infected with Leishmania major

21 January 2018

1 reference

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response

21 January 2018

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Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

21 January 2018

1 reference

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

21 January 2018

1 reference

The human model: a genetic dissection of immunity to infection in natural conditions

21 January 2018

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Development of Th1-type immune responses requires the type I cytokine receptor TCCR

21 January 2018

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Antibodies to interleukin 12 abrogate established experimental colitis in mice

21 January 2018

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Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

21 January 2018

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Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

21 January 2018

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Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

21 January 2018

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

21 January 2018

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

21 January 2018

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Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

21 January 2018

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IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

21 January 2018

1 reference

Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice

21 January 2018

1 reference

IL-12 and IL-23: master regulators of innate and adaptive immunity.

21 January 2018

1 reference

p47 GTPases: regulators of immunity to intracellular pathogens

21 January 2018

1 reference

Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

21 January 2018

1 reference

IL-12 is required to maintain a Th1 response during Leishmania major infection.

21 January 2018

1 reference

In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70.

21 January 2018

1 reference

IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis.

21 January 2018

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A protective and agonistic function of IL-12p40 in mycobacterial infection.

21 January 2018

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IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12.

21 January 2018

1 reference

Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense

21 January 2018

1 reference

Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection.

21 January 2018

1 reference

Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection

21 January 2018

1 reference

IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together

21 January 2018

1 reference

STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection.

21 January 2018

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Divergent role of gamma interferon in a murine model of pulmonary versus systemic Klebsiella pneumoniae infection

21 January 2018

1 reference

Interferon-gamma: the major mediator of resistance against Toxoplasma gondii

21 January 2018

1 reference

Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii

21 January 2018

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Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii

21 January 2018

1 reference

Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.

21 January 2018

1 reference

Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

21 January 2018

1 reference

IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells

21 January 2018

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IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

21 January 2018

1 reference

An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells

21 January 2018

1 reference

Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection.

21 January 2018

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Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major

21 January 2018

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Understanding the pro- and anti-inflammatory properties of IL-27.

21 January 2018

1 reference

Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals.

21 January 2018

1 reference

Adjuvant activities of novel cytokines, interleukin-23 (IL-23) and IL-27, for induction of hepatitis C virus-specific cytotoxic T lymphocytes in HLA-A*0201 transgenic mice.

21 January 2018

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IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells

21 January 2018

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Potent antitumor activity of interleukin-27.

21 January 2018

1 reference

Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells

21 January 2018

1 reference

Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27.

21 January 2018

1 reference

Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27.

21 January 2018

1 reference

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice

21 January 2018

1 reference

WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production

21 January 2018

1 reference

The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.

21 January 2018

1 reference

Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis

21 January 2018

1 reference

Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.

21 January 2018

1 reference

WSX-1: a key role in induction of chronic intestinal nematode infection.

21 January 2018

1 reference

Lymphocyte responses and cytokines

21 January 2018

1 reference

Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine

21 January 2018

1 reference

Analysis of the sinusitis nasal lavage fluid proteome using capillary liquid chromatography interfaced to electrospray ionization-quadrupole time of flight- tandem mass spectrometry.

21 January 2018

1 reference

Increased expression of interleukin 17 in inflammatory bowel disease

21 January 2018

1 reference

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

21 January 2018

1 reference

Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

21 January 2018

1 reference

Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

21 January 2018

1 reference

Anti-interleukin-12 antibody for active Crohn's disease

21 January 2018

1 reference

Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management

21 January 2018

1 reference

Expression of IL-27 in human Th1-associated granulomatous diseases

21 January 2018

1 reference

The expression of IL-12 p40 and its homologue, Epstein-Barr virus-induced gene 3, in inflammatory bowel disease

21 January 2018

1 reference

Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

21 January 2018

1 reference

Inhibition of interferon gamma induced interleukin 12 production: a potential mechanism for the anti-inflammatory activities of tumor necrosis factor

21 January 2018

1 reference

Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling

21 January 2018

1 reference

Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

21 January 2018

1 reference

Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection

21 January 2018

1 reference

STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gamma

21 January 2018

1 reference

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

21 January 2018

1 reference

Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells

21 January 2018

1 reference

Interleukin-17 family members and inflammation

21 January 2018

1 reference

T(H)1 and T(H)2 cells: a historical perspective

21 January 2018

1 reference

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

31 March 2020

1 reference

Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice

31 March 2020

1 reference

Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis

31 March 2020

1 reference

IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination

31 March 2020

1 reference

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice

31 March 2020

1 reference

The role of endogenous interleukin-12 in resistance to murine cytomegalovirus (MCMV) infection and a novel action for endogenous IL-12 p40

31 March 2020

1 reference

The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

31 March 2020

1 reference

The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis

31 March 2020

1 reference

IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice

31 March 2020

1 reference

IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-gamma when combined with IL-18

31 March 2020

1 reference

A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1648

1 reference

12 August 2017

1 reference

PubMed ID

15999093