A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex (Q33812633)

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English	A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex	scientific article

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scholarly article

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Europe PubMed Central

29 July 2017

A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex (English)

1 reference

Europe PubMed Central

29 July 2017

9

object named as

Yves Pommier

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Europe PubMed Central

29 July 2017

7

object named as

Alex B Burgin

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Europe PubMed Central

29 July 2017

author name string

Christophe Marchand

1

1 reference

Europe PubMed Central

29 July 2017

Smitha Antony

2

1 reference

Europe PubMed Central

29 July 2017

Kurt W Kohn

3

1 reference

Europe PubMed Central

29 July 2017

Mark Cushman

4

1 reference

Europe PubMed Central

29 July 2017

Alexandra Ioanoviciu

5

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Europe PubMed Central

29 July 2017

Bart L Staker

6

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Europe PubMed Central

29 July 2017

Lance Stewart

8

1 reference

Europe PubMed Central

29 July 2017

publication date

1 February 2006

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Europe PubMed Central

29 July 2017

Molecular Cancer Therapeutics

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Europe PubMed Central

29 July 2017

5

1 reference

Europe PubMed Central

29 July 2017

2

1 reference

Europe PubMed Central

29 July 2017

287-295

1 reference

Europe PubMed Central

29 July 2017

Interfacial inhibitors of protein-nucleic acid interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860177

4 July 2018

Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860177

4 July 2018

Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860177

4 July 2018

Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860177

4 July 2018

Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860177

4 July 2018

Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860177

4 July 2018

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

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Camptothecin: current perspectives

1 reference

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Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism

1 reference

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4 July 2018

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

1 reference

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The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I

1 reference

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Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.

1 reference

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Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187

1 reference

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4 July 2018

The camptothecins.

1 reference

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4 July 2018

DNA relaxation by human topoisomerase I occurs in the closed clamp conformation of the protein

1 reference

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Non-camptothecin DNA topoisomerase I inhibitors in cancer therapy

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

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Cellular roles of dna topoisomerases: a molecular perspective

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Different effects on human topoisomerase I by minor groove and intercalated deoxyguanosine adducts derived from two polycyclic aromatic hydrocarbon diol epoxides at or near a normal cleavage site

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Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution

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DNA topoisomerases: structure, function, and mechanism

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Use of camptothecin-resistant mammalian cell lines to evaluate the role of topoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site.

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Structural studies of the translational apparatus

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Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.

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A model for the mechanism of human topoisomerase I

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The domain organization of human topoisomerase I

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Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

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Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture

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Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

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Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I

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Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids

1 reference

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Topoisomerase I inhibitors: selectivity and cellular resistance.

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30 October 2018

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/16505102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16505102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural basis of camptothecin interactions with human serum albumin: impact on drug stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/16505102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16505102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/16505102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-05-0456

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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