Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation (Q33819279)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24845457%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation (English)

1 reference

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18 March 2020

0 references

Joyonna Gamble-George

series ordinal

2

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18 March 2020

3

Lawrence J Marnett

1 reference

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18 March 2020

1

Daniel J Hermanson

1 reference

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18 March 2020

author name string

Sachin Patel

series ordinal

4

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18 March 2020

publication date

18 May 2014

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24845457%20AND%20SRC:MED&resulttype=core&format=json

Trends in Pharmacological Sciences

18 March 2020

published in

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18 March 2020

volume

35

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18 March 2020

issue

7

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18 March 2020

page(s)

358-367

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Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase

18 March 2020

cites work

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Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib

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Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

28 July 2018

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Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides

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Anandamide-derived prostamide F2α negatively regulates adipogenesis

28 July 2018

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28 July 2018

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Methodology of a large prospective, randomised, open, blinded endpoint streamlined safety study of celecoxib versus traditional non-steroidal anti-inflammatory drugs in patients with osteoarthritis or rheumatoid arthritis: protocol of the standard c

28 July 2018

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Therapeutic potential of monoacylglycerol lipase inhibitors

28 July 2018

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Why do cannabinoid receptors have more than one endogenous ligand?

28 July 2018

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Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

28 July 2018

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Peroxisome proliferator-activated receptor α mediates acute effects of palmitoylethanolamide on sensory neurons

28 July 2018

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The endocannabinoid system and the brain

28 July 2018

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Physiology. COX-2 inhibitors and cardiovascular risk

28 July 2018

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Production and actions of the anandamide metabolite prostamide E2 in the renal medulla

28 July 2018

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Vascular COX-2 modulates blood pressure and thrombosis in mice.

28 July 2018

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Manifold beneficial effects of acetyl salicylic acid and nonsteroidal anti-inflammatory drugs on sepsis.

28 July 2018

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Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

28 July 2018

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Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice

28 July 2018

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(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

28 July 2018

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Cannabinoids, endocannabinoids, and cancer

28 July 2018

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Non-steroidal anti-inflammatory drug (NSAID) related inhibition of aldosterone glucuronidation and arterial dysfunction in patients with rheumatoid arthritis: a cross-sectional clinical study

28 July 2018

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Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

28 July 2018

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COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation

28 July 2018

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The Structural Basis of Endocannabinoid Oxygenation by Cyclooxygenase-2

28 July 2018

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Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer

28 July 2018

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Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

28 July 2018

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Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2

28 July 2018

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Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system

28 July 2018

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28 July 2018

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Cyclooxygenase-2 mediates anandamide metabolism in the mouse brain

28 July 2018

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The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

28 July 2018

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Priming innate immune responses to infection by cyclooxygenase inhibition kills antibiotic-susceptible and -resistant bacteria

28 July 2018

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Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids

28 July 2018

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Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2alpha glyceryl esters in RAW 264.7 cells and H1819 cells

28 July 2018

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FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels

28 July 2018

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Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

28 July 2018

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28 July 2018

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The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants

28 July 2018

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Cyclooxygenase Allosterism, Fatty Acid-mediated Cross-talk between Monomers of Cyclooxygenase Homodimers

28 July 2018

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Endocannabinoid-mediated control of synaptic transmission

28 July 2018

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Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes

28 July 2018

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28 July 2018

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Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

28 July 2018

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Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity

28 July 2018

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COX-2 oxidative metabolism of endocannabinoids augments hippocampal synaptic plasticity

28 July 2018

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COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs

28 July 2018

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COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity.

28 July 2018

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The 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation system

28 July 2018

1 reference

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New insights into endocannabinoid degradation and its therapeutic potential

28 July 2018

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The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine

28 July 2018

1 reference

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Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus

28 July 2018

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Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation

28 July 2018

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Bimatoprost: a novel antiglaucoma agent

28 July 2018

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The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells

28 July 2018

1 reference

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Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism

28 July 2018

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The molecular logic of endocannabinoid signalling

28 July 2018

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Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha

28 July 2018

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A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

28 July 2018

1 reference

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The cyclooxygenase reaction mechanism

28 July 2018

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Modulation of anxiety through blockade of anandamide hydrolysis

28 July 2018

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Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides

28 July 2018

1 reference

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COX-2: a target for colon cancer prevention

28 July 2018

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Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

28 July 2018

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Cyclooxygenases: structural, cellular, and molecular biology

28 July 2018

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Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.

28 July 2018

1 reference

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A mechanistic study of self-inactivation of the peroxidase activity in prostaglandin H synthase-1

28 July 2018

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28 July 2018

Cyclooxygenases 1 and 2

1 reference

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Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2.

28 July 2018

1 reference

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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

28 July 2018

1 reference

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COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex

28 July 2018

1 reference

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NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions

28 July 2018

1 reference

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Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2

28 July 2018

1 reference

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The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

28 July 2018

1 reference

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Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Localization of prostaglandin endoperoxide synthase-1 to the endoplasmic reticulum and nuclear envelope is independent of its C-terminal tetrapeptide-PTEL.

28 July 2018

1 reference

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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Discovery of prostamide F2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability

28 July 2018

1 reference

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Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses.

29 October 2018

1 reference

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Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Disease-modifying treatments for Alzheimer's disease: a perspective based on experience with R-Flurbiprofen.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

The endocannabinoid system: a drug discovery perspective.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Bioinversion of R-flurbiprofen to S-flurbiprofen at various dose levels in rat, mouse, and monkey

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

A role for endocannabinoids in indomethacin-induced spinal antinociception

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Brain monoglyceride lipase participating in endocannabinoid inactivation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Pharmacological characterization of the anandamide cyclooxygenase metabolite: prostaglandin E2 ethanolamide

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Boxing Bladder Cancer with COX-2-specific Inhibition

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4074568

Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?

29 October 2018

1 reference

12 December 2020

Higher oxidation states of prostaglandin H synthase. Rapid electronic spectroscopy detected two spectral intermediates during the peroxidase reaction with prostaglandin G2

1 reference

12 December 2020

Prostaglandin H synthase. Stoichiometry of heme cofactor

1 reference

12 December 2020

Ibuprofen inhibits the metabolism of the endogenous cannabimimetic agent anandamide

1 reference

12 December 2020

Simultaneous analysis of prostaglandin glyceryl esters and prostaglandins by electrospray tandem mass spectrometry

1 reference

12 December 2020

Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents

1 reference

12 December 2020

1 reference

12 December 2020

10.1016/J.TIPS.2014.04.006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24845457%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24845457%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference