Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype. (Q33821606)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15870195%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype (English)

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11 January 2020

2

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11 January 2020

4

Andre J van Wijnen

1 reference

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11 January 2020

6

Gary S Stein

1 reference

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11 January 2020

3

Jane B Lian

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11 January 2020

5

Janet L Stein

1 reference

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11 January 2020

1

Diana Vradii

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11 January 2020

language of work or name

English

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publication date

3 May 2005

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11 January 2020

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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11 January 2020

volume

102

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11 January 2020

page(s)

7174-7179

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11 January 2020

issue

20

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Molecular mechanisms of leukemogenesis by AML1/EVI-1.

11 January 2020

cites work

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Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

28 July 2018

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Fes tyrosine kinase promotes survival and terminal granulocyte differentiation of factor-dependent myeloid progenitors (32D) and activates lineage-specific transcription factors

28 July 2018

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Transdifferentiation and nuclear reprogramming in hematopoietic development and neoplasia

28 July 2018

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Core-binding factors in haematopoiesis and leukaemia

28 July 2018

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Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites

28 July 2018

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CCAAT/enhancer-binding proteins are required for granulopoiesis independent of their induction of the granulocyte colony-stimulating factor receptor

28 July 2018

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Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity

28 July 2018

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AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.

28 July 2018

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A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene

28 July 2018

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Role of co-repressors in transcriptional repression mediated by the t(8;21), t(16;21), t(12;21), and inv(16) fusion proteins

28 July 2018

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Alterations in subnuclear trafficking of nuclear regulatory factors in acute leukemia

28 July 2018

1 reference

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Effects of the acute myeloid leukemia--associated fusion proteins on nuclear architecture.

28 July 2018

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Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription

28 July 2018

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28 July 2018

The Hallmarks of Cancer

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Cancer and the cell cycle

28 July 2018

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Mammalian runt-domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia

28 July 2018

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The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor

28 July 2018

1 reference

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The PML nuclear bodies: actors or extras?

28 July 2018

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Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors

28 July 2018

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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

28 July 2018

1 reference

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Development of the hematopoietic system

28 July 2018

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Nuclear domains involved in RNA synthesis, RNA processing, and replication.

28 July 2018

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Cell differentiation in acute myeloid leukemia.

28 July 2018

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DNA-binding domain of AML1, expressed in t(8;21) and t(3;21) myeloid leukemias, inhibits PEBP2/CBF DNA-binding but is not sufficient to transform 32D cl3 myeloid cells.

28 July 2018

1 reference

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Transforming growth factor-beta1 modulates p107 function in myeloid cells: correlation with cell cycle progression

28 July 2018

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Transcriptional regulation of two myeloid-specific genes, myeloperoxidase and lactoferrin, during differentiation of the murine cell line 32D C13

28 July 2018

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Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair.

28 July 2018

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Protein dynamics: implications for nuclear architecture and gene expression.

21 January 2018

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Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins

21 January 2018

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Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal

21 January 2018

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Hyperplasia and impaired involution in the mammary gland of transgenic mice expressing human FGF4.

21 January 2018

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Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

21 January 2018

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Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.

21 January 2018

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The molecular biology of acute myeloid leukemia. Proto-oncogene expression and function in normal and neoplastic myeloid cells.

29 October 2018

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Regulation of granulopoiesis

29 October 2018

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12 December 2020

Evidence for specific receptors for interleukin 3 on lymphokine-dependent cell lines established from long-term bone marrow cultures

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12 December 2020

Cytologic diagnosis of the acute nonlymphoid leukemias. II. Flow cytometry, surface markers, cytogenetics, and use of cell culture techniques

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12 December 2020

Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line

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12 December 2020

Cellular control of in vitro progression of murine myeloid leukemia: progression accompanies acquisition of independence from growth factor and stromal cells

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12 December 2020

Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8;21): only myeloid cells are part of the malignant clone

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0502130102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15870195%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

0 references

1 reference

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11 January 2020

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