Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling (Q33842473)

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English	Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

29 July 2017

Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling (English)

1 reference

Europe PubMed Central

29 July 2017

Cytomegalovirus

0 references

author name string

R A Johnson

1

1 reference

Europe PubMed Central

29 July 2017

X Wang

2

1 reference

Europe PubMed Central

29 July 2017

X L Ma

3

1 reference

Europe PubMed Central

29 July 2017

S M Huong

4

1 reference

Europe PubMed Central

29 July 2017

E S Huang

5

1 reference

Europe PubMed Central

29 July 2017

publication date

1 July 2001

1 reference

Europe PubMed Central

29 July 2017

Journal of Virology

1 reference

Europe PubMed Central

29 July 2017

75

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Europe PubMed Central

29 July 2017

6022-6032

1 reference

Europe PubMed Central

29 July 2017

13

1 reference

Europe PubMed Central

29 July 2017

Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin

1 reference

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5 July 2018

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

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Activation of the mitogen-activated protein kinase p38 by human cytomegalovirus infection through two distinct pathways: a novel mechanism for activation of p38.

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Signaling by distinct classes of phosphoinositide 3-kinases

1 reference

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

1 reference

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Ribosomal S6 kinase signaling and the control of translation

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Modulation of cellular apoptotic potential: contributions to oncogenesis

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A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes

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Induction of NF-kappaB by the Akt/PKB kinase

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Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

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Inhibitory effect of 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H - imidazole on HCMV DNA replication and permissive infection

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Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathway

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Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.

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Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.

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5 July 2018

Phosphoinositide kinases

1 reference

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5 July 2018

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1 reference

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5 July 2018

Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation

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5 July 2018

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

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Human cytomegalovirus infection results in altered Cdk2 subcellular localization

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5 July 2018

The modular phosphorylation and activation of p70s6k.

1 reference

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5 July 2018

Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

1 reference

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5 July 2018

Signalling through the lipid products of phosphoinositide-3-OH kinase

1 reference

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5 July 2018

The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection

1 reference

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5 July 2018

Inhibition of cellular Cdk2 activity blocks human cytomegalovirus replication

1 reference

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5 July 2018

Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters

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Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1 reference

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5 July 2018

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

1 reference

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5 July 2018

p70 S6 kinase: an enigma with variations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=114318

5 July 2018

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

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The NF-kappa B and I kappa B proteins: new discoveries and insights

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Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity.

1 reference

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Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

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The human cytomegalovirus UL94 open reading frame encodes a conserved herpesvirus capsid/tegument-associated virion protein that is expressed with true late kinetics.

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PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

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Promoter of the human NF-kappa B p50/p105 gene. Regulation by NF-kappa B subunits and by c-REL.

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5 July 2018

NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule

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5 July 2018

Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection

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Increased levels of sequence-specific DNA-binding proteins in human cytomegalovirus-infected cells

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Eleven loci encoding trans-acting factors are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA replication.

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5 July 2018

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

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5 July 2018

Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters

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Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

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Identifiers

10.1128/JVI.75.13.6022-6032.2001

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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