Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle (Q33849340)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24813857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle (English)

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18 March 2020

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2

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18 March 2020

4

Irving L Weissman

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18 March 2020

author name string

Isabel Beerman

series ordinal

1

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18 March 2020

Matthew A Inlay

series ordinal

3

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18 March 2020

Derrick J Rossi

series ordinal

5

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18 March 2020

language of work or name

English

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publication date

8 May 2014

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18 March 2020

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18 March 2020

volume

15

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18 March 2020

issue

1

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18 March 2020

page(s)

37-50

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Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

18 March 2020

cites work

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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

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FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors

5 July 2018

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Stem cell metabolism in tissue development and aging

5 July 2018

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Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

5 July 2018

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Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes

5 July 2018

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

5 July 2018

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Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair.

5 July 2018

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Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells

5 July 2018

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Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

5 July 2018

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Gene Expression Commons: an open platform for absolute gene expression profiling

5 July 2018

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Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

5 July 2018

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Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation

5 July 2018

1 reference

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A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage

5 July 2018

1 reference

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Clonal evolution of acute leukemia genomes

5 July 2018

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Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.

5 July 2018

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Cell cycle regulation in hematopoietic stem cells

5 July 2018

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Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

5 July 2018

1 reference

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Metabolic regulation of hematopoietic stem cells in the hypoxic niche

5 July 2018

1 reference

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Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging

5 July 2018

1 reference

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Regulation of the HIF-1alpha level is essential for hematopoietic stem cells

5 July 2018

1 reference

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Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

5 July 2018

1 reference

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Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.

5 July 2018

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Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

5 July 2018

1 reference

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Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.

5 July 2018

1 reference

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A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

DNA repair is limiting for haematopoietic stem cells during ageing

5 July 2018

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Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

5 July 2018

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Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect

5 July 2018

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Telomerase regulation and stem cell behaviour

5 July 2018

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Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates

5 July 2018

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Stem cell research: paths to cancer therapies and regenerative medicine

5 July 2018

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Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia

5 July 2018

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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

5 July 2018

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Cell intrinsic alterations underlie hematopoietic stem cell aging.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

A direct measurement of the radiation sensitivity of normal mouse bone marrow cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Significance analysis of microarrays applied to the ionizing radiation response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Analysis of DNA damage in individual cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Age-associated characteristics of murine hematopoietic stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Telomerase activity in normal and malignant hematopoietic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

The purification and characterization of fetal liver hematopoietic stem cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Studies of hematopoietic stem cells spared by 5-fluorouracil

5 July 2018

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A simple technique for quantitation of low levels of DNA damage in individual cells

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Persistent malignant stem cells in del(5q) myelodysplasia in remission

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

29 October 2018

1 reference

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Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Telomerase activity in hematopoietic cells is associated with self-renewal potential

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082747

Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil.

29 October 2018

1 reference

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p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells

29 October 2018

1 reference

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Activation of telomerase in human lymphocytes and hematopoietic progenitor cells

29 October 2018

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12 December 2020

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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12 December 2020

Reliable Comet assay measurements for detecting DNA damage induced by ionising radiation and chemicals

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12 December 2020

The comet assay: a method to measure DNA damage in individual cells

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12 December 2020

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

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12 December 2020

10.1016/J.STEM.2014.04.016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24813857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24813857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

24813857

1 reference