Native MS: an 'ESI' way to support structure- and fragment-based drug discovery (Q33852381)

29 July 2017

Native MS: an 'ESI' way to support structure- and fragment-based drug discovery (English)

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29 July 2017

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Valerie Vivat Hannah

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29 July 2017

C Atmanene

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29 July 2017

D Zeyer

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29 July 2017

A Van Dorsselaer

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29 July 2017

Sarah Sanglier-Cianférani

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29 July 2017

1 January 2010

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Future Medicinal Chemistry

29 July 2017

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29 July 2017

2

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29 July 2017

1

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29 July 2017

35-50

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Drug discovery: a historical perspective

29 July 2017

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Studying noncovalent protein complexes by electrospray ionization mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Influence of pressure in the first pumping stage on analyte desolvation and fragmentation in nano-ESI MS.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Collisional cooling of large ions in electrospray mass spectrometry.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Native mass spectrometry: a bridge between interactomics and structural biology

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

In vitro reconstitution of the human RISC-loading complex

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Subunit architecture of intact protein complexes from mass spectrometry and homology modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Structure of an Hsp90-Cdc37-Cdk4 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Mass spectrometric studies of potent inhibitors of farnesyl protein transferase--detection of pentameric noncovalent complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Studies on ternary metallo-beta lactamase-inhibitor complexes using electrospray ionization mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Potential inhibitors of chemokine function: analysis of noncovalent complexes of CC chemokine and small polyanionic molecules by ESI FT-ICR mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Investigation of molecular interaction within biological macromolecular complexes by mass spectrometry.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Ligand-metal ion binding to proteins: investigation by ESI mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Mass spectrometry-based approaches to protein-ligand interactions

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Crystal structure of Thermus thermophilus tRNA m1A58 methyltransferase and biophysical characterization of its interaction with tRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Study of a noncovalent trp repressor: DNA operator complex by electrospray ionization time-of-flight mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Noncovalent probes for the investigation of structure and dynamics of protein-nucleic acid assemblies: the case of NC-mediated dimerization of genomic RNA in HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Hybridization of short complementary PNAs to G-quadruplex forming oligonucleotides: An electrospray mass spectrometry study

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Cooperative 2:1 binding of a bisphenothiazine to duplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Investigation of double-stranded DNA/drug interaction by ESI/FT ICR: orientation of dissociations relates to stabilizing salt bridges

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Oligomerization behavior of the archaeal Sm2-type protein from Archaeoglobus fulgidus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Native protein mass spectrometry: from intact oligomers to functional machineries.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Extending mass spectrometry contribution to therapeutic monoclonal antibody lead optimization: characterization of immune complexes using noncovalent ESI-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Mass spectrometry of intact ribosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Electrospray ionization mass spectrometry and ion mobility analysis of the 20S proteasome complex

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Insights into virus capsid assembly from non-covalent mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

The role of mass spectrometry in structure elucidation of dynamic protein complexes

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

High-resolution mass spectrometry of viral assemblies: molecular composition and stability of dimorphic hepatitis B virus capsids.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Identifying nonspecific ligand binding in electrospray ionization mass spectrometry using the reporter molecule method

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Non-covalent binding of endogenous ligands to recombinant cellular retinol-binding proteins studied by mass spectrometric techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Using nondenaturing mass spectrometry to detect fortuitous ligands in orphan nuclear receptors

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Identification of natural ligands of retinoic acid receptor-related orphan receptor α ligand-binding domain expressed in Sf9 cells––a mass spectrometry approach

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Molecular dynamics simulations of human LRH-1: the impact of ligand binding in a constitutively active nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Crystal Structure of the Transcriptional Regulator CmeR from Campylobacter jejuni

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Structural change in response to ligand binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Monitoring ligand-mediated nuclear receptor-coregulator interactions by noncovalent mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Monitoring ligand modulation of protein-protein interactions by mass spectrometry: estrogen receptor alpha-SRC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

An integrative approach combining noncovalent mass spectrometry, enzyme kinetics and X-ray crystallography to decipher Tgt protein-protein and protein-RNA interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Quantitative determination of lysozyme-ligand binding in the solution and gas phases by electrospray ionisation mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Estrogen receptor-ligand complexes measured by chip-based nanoelectrospray mass spectrometry: an approach for the screening of endocrine disruptors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Recent developments in fragment-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

A decade of fragment-based drug design: strategic advances and lessons learned

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.141

Fragment approaches in structure-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Biophysical techniques for ligand screening and drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Discovering novel ligands for macromolecules using X-ray crystallographic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

SAR by MS: a ligand based technique for drug lead discovery against structured RNA targets

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Structure-activity relationships by mass spectrometry: identification of novel MMP-3 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Direct screening of a dynamic combinatorial library using mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Targeting HSP90 for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Quantitative determination of noncovalent binding interactions using automated nanoelectrospray mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Use of a microchip device coupled with mass spectrometry for ligand screening of a multi-protein target

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Automated nano-electrospray mass spectrometry for protein-ligand screening by noncovalent interaction applied to human H-FABP and A-FABP.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Electrospray ionization of a whole virus: analyzing mass, structure, and viability

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Probing genuine strong interactions and post-translational modifications in the heterogeneous yeast exosome protein complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

The yeast Ski complex is a hetero-tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Micelles protect membrane complexes from solution to vacuum.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Evidence for macromolecular protein rings in the absence of bulk water.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Subunit architecture of multiprotein assemblies determined using restraints from gas-phase measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Gas-phase unfolding and disassembly reveals stability differences in ligand-bound multiprotein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Collision induced unfolding of protein ions in the gas phase studied by ion mobility-mass spectrometry: the effect of ligand binding on conformational stability

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

An Ion Mobility-Mass Spectrometry Investigation of Monocyte Chemoattractant Protein-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Nondenaturing mass spectrometry to study noncovalent protein/protein and protein/ligand complexes: technical aspects and application to the determination of binding stoichiometries.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

The effect of the source pressure on the abundance of ions of noncovalent protein assemblies in an electrospray ionization orthogonal time-of-flight instrument

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Using Electrospray Ionization FTICR Mass Spectrometry To Study Competitive Binding of Inhibitors to Carbonic Anhydrase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

Carbonic Anhydrase-Inhibitor Binding: From Solution to the Gas Phase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.141

21 January 2018

Identifiers

DOI

10.4155/FMC.09.141

1 reference

29 July 2017

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