Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM. (Q33853600)

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English	Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM. (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

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7

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Garth Powis

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Europe PubMed Central

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29 July 2017

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Yong-Wan Kim

1

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Europe PubMed Central

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29 July 2017

Ta Jen Liu

2

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Europe PubMed Central

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29 July 2017

Dimpy Koul

3

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Europe PubMed Central

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29 July 2017

Ningyi Tiao

4

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Europe PubMed Central

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29 July 2017

Abdullah H Feroze

5

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Europe PubMed Central

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29 July 2017

Jing Wang

6

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Europe PubMed Central

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29 July 2017

W K Alfred Yung

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29 July 2017

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1 April 2011

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Europe PubMed Central

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29 July 2017

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Europe PubMed Central

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29 July 2017

13

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Europe PubMed Central

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29 July 2017

4

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Europe PubMed Central

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29 July 2017

367-375

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Europe PubMed Central

PubMed publication ID

29 July 2017

Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma

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NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

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5 July 2018

Synthetic lethality--a new direction in cancer-drug development

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Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes

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Exploring multi-targeting strategies for the treatment of gliomas

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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5 July 2018

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

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Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

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New molecular targets in malignant gliomas

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5 July 2018

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

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Utilizing RNA interference to enhance cancer drug discovery

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Genome-wide functional analysis of human cell-cycle regulators.

1 reference

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5 July 2018

Building mammalian signalling pathways with RNAi screens

1 reference

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5 July 2018

Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme

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5 July 2018

The concept of synthetic lethality in the context of anticancer therapy

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5 July 2018

Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme

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5 July 2018

Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition.

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5 July 2018

Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

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5 July 2018

Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas.

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5 July 2018

Estimating the occurrence of false positives and false negatives in microarray studies by approximating and partitioning the empirical distribution of p-values

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5 July 2018

Expression profiling reveals off-target gene regulation by RNAi

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Nonprimate lentiviral vectors.

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Genetic synthetic lethality screen at the single gene level in cultured human cells

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Erlotinib in gliomas: should selection be based on EGFR and Akt analyses?

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Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

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Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment

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Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population

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21 January 2018

High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer

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12 December 2020

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Lethal combinations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21430111

12 December 2020

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PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress

1 reference

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12 December 2020

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mTOR inhibitors in the treatment of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21430111

12 December 2020

based on heuristic

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10.1093/NEUONC/NOR012

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Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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