Overexpression of enzymes that repair endogenous damage to DNA. (Q33888666)

29 July 2017

1 reference

title

Overexpression of enzymes that repair endogenous damage to DNA. (English)

1 reference

29 July 2017

1 reference

G Frosina

1

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PubMed ID

10759836

29 July 2017

language of work or name

English

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publication date

1 April 2000

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29 July 2017

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29 July 2017

267

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29 July 2017

8

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29 July 2017

2135-2149

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Instability and decay of the primary structure of DNA

29 July 2017

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Mutagenesis by 8-oxoguanine: an enemy within

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

21 January 2018

Oxidative Decay of DNA

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Internal hazards: baseline DNA damage by endogenous products of normal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Repair of oxidative damage to DNA: enzymology and biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The base excision repair pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

21 January 2018

Life without DNA repair

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Repair of oxidized DNA bases in the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Base excision repair of 8-hydroxyguanine protects DNA from endogenous oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Oxidative DNA damage processing in nuclear and mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Mismatch repair: mechanisms and relationship to cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

DNA-repair methyltransferase as a molecular device for preventing mutation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: the role of DNA base damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Excision repair of thymine glycols, urea residues, and apurinic sites in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Endogenous DNA adducts: potential and paradox

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The CpG dinucleotide and human genetic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Requirement of mammalian DNA polymerase-beta in base-excision repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

A novel activity of E. coli uracil DNA N-glycosylase excision of isodialuric acid (5,6-dihydroxyuracil), a major product of oxidative DNA damage, from DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

3-methyladenine DNA glycosylases: structure, function, and biological importance

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Escherichia coli, Saccharomyces cerevisiae, rat and human 3-methyladenine DNA glycosylases repair 1,N6-ethenoadenine when present in DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

DNA glycosylases in the base excision repair of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Two distinct human DNA diesterases that hydrolyze 3′-blocking deoxyribose fragments from oxidized DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The Drosophila ribosomal protein S3 contains a DNA deoxyribophosphodiesterase (dRpase) activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Generation of single-nucleotide repair patches following excision of uracil residues from DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

XRCC1 protein interacts with one of two distinct forms of DNA ligase III

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Quality control by DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Antimutagenic role of base-excision repair enzymes upon free radical-induced DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

mutM, a second mutator locus in Escherichia coli that generates G.C----T.A transversions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Escherichia coli endonuclease VIII: cloning, sequencing, and overexpression of the nei structural gene and characterization of nei and nei nth mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Characterization of endonuclease III (nth) and endonuclease VIII (nei) mutants of Escherichia coli K-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Inactivation of OGG1 increases the incidence of G . C-->T . A transversions in Saccharomyces cerevisiae: evidence for endogenous oxidative damage to DNA in eukaryotic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Saccharomyces cerevisiae Ntg1p and Ntg2p: broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Alkylation carcinogenesis in mice with altered levels of DNA repair methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Human uracil-DNA glycosylase complements E. coli ung mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Role of uracil-DNA glycosylase in mutation avoidance by Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Selection by genetic transformation of a Saccharomyces cerevisiae mutant defective for the nuclear uracil-DNA-glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Endonuclease III (nth) mutants of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Role of exonuclease III and endonuclease IV in repair of pyrimidine dimers initiated by bacteriophage T4 pyrimidine dimer-DNA glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Normal processing of AP sites in Apn1-deficient Saccharomyces cerevisiae is restored by Escherichia coli genes expressing either exonuclease III or endonuclease III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Identification of redox/repair protein Ref-1 as a potent activator of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

A Chinese hamster ovary cell mutant (EM-C11) with sensitivity to simple alkylating agents and a very high level of sister chromatid exchanges

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Requirement for the Xrcc1 DNA base excision repair gene during early mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Repair of abasic sites by mammalian cell extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Regulated expression of APE apurinic endonuclease mRNA during wound healing in porcine epidermis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Repair of products of oxidative DNA base damage in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

DNA repair functions in heterologous cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Identification of human genes involved in repair and tolerance of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Expression of the E. coli fpg gene in mammalian cells reduces the mutagenicity of gamma-rays

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Reduction of the toxicity and mutagenicity of aziridine in mammalian cells harboring the Escherichia coli fpg gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Overexpression of Ogg1 in mammalian cells: effects on induced and spontaneous oxidative DNA damage and mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Effect of alkyl-N-purine DNA glycosylase overexpression on cellular resistance to bifunctional alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Release of normal bases from intact DNA by a native DNA repair enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Generation of a strong mutator phenotype in yeast by imbalanced base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The influence of DNA glycosylases on spontaneous mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Increased resistance of the Chinese hamster mutant irs1 cells to monofunctional alkylating agents by transfection of the E. coli or mammalian N3-methyladenine-DNA-glycosylase genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG) in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Increased removal of 3-alkyladenine reduces the frequencies of hprt mutations induced by methyl- and ethylmethanesulfonate in Chinese hamster fibroblast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

3T3 NIH murine fibroblasts and B78 murine melanoma cells expressing the Escherichia coli N3-methyladenine-DNA glycosylase I do not become resistant to alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Regulation of eukaryotic abasic endonucleases and their role in genetic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Dominant negative rat DNA polymerase beta mutants interfere with base excision repair in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Effect of transfection of human poly(ADP-ribose)polymerase in Chinese hamster cells on mutagen resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Expression in mammalian cells of a truncated Escherichia coli gene coding for O6-alkylguanine alkyltransferase reduces the toxic effects of alkylating agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Chinese hamster cells harbouring the Escherichia coli O6-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Cytotoxicity, mutations and SCEs induced by methylating agents are reduced in CHO cells expressing an active mammalian O6-methylguanine-DNA methyltransferase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Protection of Chinese hamster cells against the cytotoxic and mutagenic effects of alkylating agents by transfection of the Escherichia coli alkyltransferase gene and a truncated derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Expression of an E.coli O6-alkylguanine DNA alkyltransferase gene in Chinese hamster cells protects against N-methyl and N-ethylnitrosourea induced reverse mutation at the hypoxanthine phosphoribosyl transferase locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Expression in mammalian cells of the Escherichia coli O6 alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Mammalian cells expressing Escherichia coli O6-alkylguanine-DNA alkyltransferases are hypersensitive to dibromoalkanes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Brain and liver targeted overexpression of O6-methylguanine DNA methyltransferase in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Alkyltransferase transgenic mice: probes of chemical carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Increased drug resistance following retroviral gene transfer of a chimeric P-enolpyruvate carboxykinase (GTP)-bacterial O6-alkylguanine-DNA alkyltransferase gene into NRK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Chemoprotection of normal tissues by transfer of drug resistance genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Transfection of murine multi-potent haemopoietic stem cells with an E. coli DNA alkyltransferase gene confers resistance to the toxic effects of alkylating agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Spontaneous mutagenesis in mammalian cells is caused mainly by oxidative events and can be blocked by antioxidants and metallothionein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Transfer of human genes conferring resistance to methylating mutagens, but not to UV irradiation and cross-linking agents, into Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

The Escherichia coli AlkB protein protects human cells against alkylation-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

Relationships between DNA repair and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01266.X

10.1046/J.1432-1327.2000.01266.X

21 January 2018

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10759836