CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile (Q33898107)

29 July 2017

title

CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile (English)

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29 July 2017

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6

Maria Almira Correia

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29 July 2017

Ping Kang

1

1 reference

29 July 2017

Mingxiang Liao

2

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29 July 2017

Michael R Wester

3

1 reference

29 July 2017

J Steven Leeder

4

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29 July 2017

Robin E Pearce

5

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29 July 2017

publication date

20 December 2007

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Drug Metabolism and Disposition

29 July 2017

published in

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29 July 2017

volume

36

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29 July 2017

issue

3

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29 July 2017

page(s)

490-499

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

29 July 2017

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5 July 2018

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5 July 2018

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29 October 2018

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29 October 2018

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The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

29 October 2018

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CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids

29 October 2018

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29 October 2018

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Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation

29 October 2018

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29 October 2018

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29 October 2018

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29 October 2018

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Identification of the heme-modified peptides from cumene hydroperoxide-inactivated cytochrome P450 3A4.

29 October 2018

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29 October 2018

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Human cytochrome P450 3A4-catalyzed testosterone 6 beta-hydroxylation and erythromycin N-demethylation. Competition during catalysis.

29 October 2018

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29 October 2018

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29 October 2018

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29 October 2018

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The Ferrous-Dioxygen Intermediate in Human Cytochrome P450 3A4

29 October 2018

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Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s)

10 December 2018

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12 December 2020

Protein-reactive metabolites of carbamazepine in mouse liver microsomes

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12 December 2020

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

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12 December 2020

Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs

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12 December 2020

Identifiers

DOI

10.1124/DMD.107.016501

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29 July 2017

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29 July 2017

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