Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion (Q33903491)

29 July 2017

Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion (English)

1 reference

29 July 2017

3

Larry A Sklar

1 reference

29 July 2017

Alexandre Chigaev

1

1 reference

PubMed ID

21586157

29 July 2017

Yelena Smagley

series ordinal

2

1 reference

29 July 2017

17 May 2011

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29 July 2017

1 reference

29 July 2017

12

1 reference

29 July 2017

28

1 reference

Creative Commons Attribution 2.0 Generic

29 July 2017

start time

17 May 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

exact match

https://scigraph.springernature.com/pub.10.1186/1471-2172-12-28

0 references

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Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion

5 July 2018

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The monoclonal anti-VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans

5 July 2018

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Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab.

5 July 2018

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Structure and mechanics of integrin-based cell adhesion.

5 July 2018

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Getting to the site of inflammation: the leukocyte adhesion cascade updated

5 July 2018

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Natalizumab and the role of alpha 4-integrin antagonism in the treatment of multiple sclerosis

5 July 2018

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Interfering with leukocyte integrin activation--a novel concept in the development of anti-inflammatory drugs

5 July 2018

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Development of monoclonal antibodies that inhibit platelet adhesion or aggregation as potential anti-thrombotic drugs.

5 July 2018

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Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism

5 July 2018

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How do stem cells find their way home?

5 July 2018

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The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.

5 July 2018

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5 July 2018

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5 July 2018

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FRET detection of cellular alpha4-integrin conformational activation.

5 July 2018

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Homing and mobilization of hematopoietic stem cells and hematopoietic cancer cells are mirror image processes, utilizing similar signaling pathways and occurring concurrently: circulating cancer cells constitute an ideal target for concurrent treatm

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

5 July 2018

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Integrins: bidirectional, allosteric signaling machines

5 July 2018

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The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

5 July 2018

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Rapid leukocyte integrin activation by chemokines

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Conformational regulation of integrin structure and function

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Taming platelets with cyclic nucleotides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

NO-independent regulatory site on soluble guanylate cyclase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Plug flow cytometry extends analytical capabilities in cell adhesion and receptor pharmacology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Cyclic nucleotide analogs as biochemical tools and prospective drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Desensitization of N-formylpeptide receptor-mediated activation is dependent upon receptor phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

"NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Signal transduction and ligand-receptor dynamics in the human neutrophil. Transient responses and occupancy-response relations at the formyl peptide receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Kinetics and amplification in neutrophil activation and adaptation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Differential modulation by N4,2′-O-dibutyryl cytidine 3′:5′-cyclic monophosphate of neutrophil activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Cytidylate cyclase: possible artifacts in the methodology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading on collagen.

5 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2172-12-28

Viagra: now mending hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2172-12-28

Actin S-nitrosylation inhibits neutrophil beta2 integrin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2172-12-28

Nitric oxide-sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2172-12-28

NO-independent stimulators of soluble guanylate cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2172-12-28

Alpha4beta1 integrin affinity changes govern cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2172-12-28

Modulation of soluble guanylate cyclase activity by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2172-12-28

The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125286

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

29 October 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2172-12-28

Undifferentiated U937 cells transfected with chemoattractant receptors: a model system to investigate chemotactic mechanisms and receptor structure/function relationships

21 January 2018

1 reference

12 December 2020

Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand

1 reference

12 December 2020

Right on the spot. Chemokine triggering of integrin-mediated arrest of rolling leukocytes

1 reference

12 December 2020

S-Nitrosylation of Platelet αIIbβ3As Revealed by Raman Spectroscopy†

1 reference

12 December 2020

Roles of cGMP/cGMP-dependent protein kinase in platelet activation

1 reference

12 December 2020

Precision substrate targeting of protein kinases. The cGMP- and cAMP-dependent protein kinases

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2172-12-28

1 reference

PubMed ID

21586157

Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference

PubMed ID

21586157