Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib (Q33906039)

29 July 2017

title

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib (English)

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29 July 2017

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6

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29 July 2017

7

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29 July 2017

D Lecis

1

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Leonardo Manzoni

object named as

L Manzoni

3

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Pierfausto Seneci

object named as

P Seneci

4

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Andrea Anichini

object named as

A Anichini

8

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Henning Walczak

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ORCID Public Data File 2021

author name string

C Drago

2

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29 July 2017

C Scolastico

5

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29 July 2017

H Kashkar

9

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29 July 2017

H Walczak

10

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29 July 2017

D Delia

11

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29 July 2017

language of work or name

English

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publication date

11 May 2010

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British Journal of Cancer

29 July 2017

published in

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29 July 2017

volume

102

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29 July 2017

issue

12

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29 July 2017

page(s)

1707-1716

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Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

29 July 2017

cites work

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5 July 2018

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SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

5 July 2018

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5 July 2018

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Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

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5 July 2018

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5 July 2018

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A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling

5 July 2018

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

5 July 2018

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

5 July 2018

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Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

5 July 2018

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Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response.

5 July 2018

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Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response

5 July 2018

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Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

5 July 2018

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Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-kappaB but is related to downregulation of initiator caspases and DR4.

5 July 2018

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5 July 2018

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E2 of hepatitis C virus inhibits apoptosis

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance.

5 July 2018

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Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

21 January 2018

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Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

21 January 2018

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Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma.

21 January 2018

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Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

21 January 2018

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Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria

21 January 2018

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12 December 2020

Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4

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12 December 2020

Clinical applications of TNF-alpha in cancer

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12 December 2020

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains

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12 December 2020

NF-kappaB-independent down-regulation of XIAP by bortezomib sensitizes HL B cells against cytotoxic drugs

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12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6605687

1 reference

Dimensions Publication ID

29 July 2017

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29 July 2017

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