Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains (Q33916854)

24878061

30 July 2017

title

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains (English)

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30 July 2017

1

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5 June 2020

Michael A Walters

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Conrad C Weihl

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5 June 2020

author name string

Stacie L Bulfer

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Kelin Li

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Lev G Lis

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Frank J Schoenen

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Henry J Lin

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Raymond J Deshaies

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Michelle R Arkin

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language of work or name

English

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publication date

27 May 2014

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24878061

Journal of Molecular Biology

30 July 2017

published in

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volume

426

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issue

15

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page(s)

2886-2899

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Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants

5 June 2020

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5 July 2018

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Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

5 July 2018

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Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase

5 July 2018

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Positive cooperativity of the p97 AAA ATPase is critical for essential functions

5 July 2018

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Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

5 July 2018

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A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants

5 July 2018

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ATP-bound form of the D1 AAA domain inhibits an essential function of Cdc48p/p97.

5 July 2018

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Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

5 July 2018

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Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation

5 July 2018

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Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease

5 July 2018

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Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

5 July 2018

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Roles of VCP in human neurodegenerative disorders

5 July 2018

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HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

5 July 2018

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The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy

5 July 2018

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The cellular basis for diverse responses to oxygen

5 July 2018

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HDAC6-p97/VCP controlled polyubiquitin chain turnover

5 July 2018

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Central pore residues mediate the p97/VCP activity required for ERAD

5 July 2018

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A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

5 July 2018

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Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

5 July 2018

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Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47

5 July 2018

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The crystal structure of murine p97/VCP at 3.6A

5 July 2018

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The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis

5 July 2018

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Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

5 July 2018

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Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

5 July 2018

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Motions and negative cooperativity between p97 domains revealed by cryo-electron microscopy and quantised elastic deformational model

5 July 2018

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Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities

5 July 2018

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VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo

5 July 2018

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ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity

5 July 2018

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5 July 2018

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

5 July 2018

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

5 July 2018

1 reference

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Structure of the AAA ATPase p97

5 July 2018

1 reference

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Mitochondria as ATP consumers: cellular treason in anoxia.

5 July 2018

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The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97

5 July 2018

1 reference

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Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro

5 July 2018

1 reference

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p47 is a cofactor for p97-mediated membrane fusion

5 July 2018

1 reference

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Isolation and characterization of the principal ATPase associated with transitional endoplasmic reticulum of rat liver

5 July 2018

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An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments

5 July 2018

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5 July 2018

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Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice

5 July 2018

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ATP depletion in macrophages in the core of advanced rabbit atherosclerotic plaques in vivo

29 October 2018

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Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering

29 October 2018

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The Janus face of the archaeal Cdc48/p97 homologue VAT: protein folding versus unfolding

29 October 2018

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12 December 2020

A Major Conformational Change in p97 AAA ATPase upon ATP Binding

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A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting

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Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships

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