Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity (Q33944212)

30 July 2017

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity (English)

1 reference

30 July 2017

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25036708%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Peter C Butler

series ordinal

5

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12 June 2020

4

Charles G Glabe

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12 June 2020

author name string

Jacqueline F Rivera

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1

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12 June 2020

Tatyana Gurlo

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3

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12 June 2020

language of work or name

English

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publication date

18 July 2014

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Journal of Clinical Investigation

30 July 2017

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12 June 2020

volume

124

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12 June 2020

page(s)

3489-3500

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12 June 2020

issue

8

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Exendin-4 improves β-cell function in autophagy-deficient β-cells

12 June 2020

cites work

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β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency

5 July 2018

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Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

5 July 2018

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A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

5 July 2018

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5 July 2018

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5 July 2018

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

5 July 2018

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Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

5 July 2018

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5 July 2018

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Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway

5 July 2018

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Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes

5 July 2018

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5 July 2018

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5 July 2018

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Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia

5 July 2018

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5 July 2018

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5 July 2018

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

5 July 2018

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5 July 2018

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Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide

5 July 2018

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High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

5 July 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

5 July 2018

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

5 July 2018

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5 July 2018

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Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model

5 July 2018

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Pepstatin, a new pepsin inhibitor produced by Actinomycetes

5 July 2018

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Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice.

5 July 2018

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Autophagy in human type 2 diabetes pancreatic beta cells.

29 October 2018

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Biochemical and morphological detection of inclusion bodies in autophagy-deficient mice.

29 October 2018

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The alpha-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice

29 October 2018

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Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

29 October 2018

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29 October 2018

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29 October 2018

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12 December 2020

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Identifiers

DOI

10.1172/JCI71981

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25036708%20AND%20SRC:MED&resulttype=core&format=json

release_u3fgy4noffg73brxovjy5drqte

12 June 2020

Fatcat ID

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24 November 2022

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12 June 2020

1 reference

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