The cytoprotective role of the Keap1-Nrf2 pathway (Q37848718)

24 August 2017

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title

The cytoprotective role of the Keap1-Nrf2 pathway (English)

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24 August 2017

Albena Dinkova-Kostova

series ordinal

2

object named as

Albena T Dinkova-Kostova

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24 August 2017

Liam Baird

1

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24 August 2017

2 March 2011

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24 August 2017

Archives of Toxicology

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24 August 2017

85

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24 August 2017

241-272

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24 August 2017

4

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https://scigraph.springernature.com/pub.10.1007/s00204-011-0674-5

24 August 2017

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Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.

21 January 2018

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Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

21 January 2018

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Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.

21 January 2018

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Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity

21 January 2018

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Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance

21 January 2018

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ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

21 January 2018

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21 January 2018

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A family of drug transporters: the multidrug resistance-associated proteins.

21 January 2018

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Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription

21 January 2018

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Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure.

21 January 2018

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Nrf2 is essential for protection against acute pulmonary injury in mice

21 January 2018

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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

21 January 2018

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Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

21 January 2018

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Gene expression profiling of NRF2-mediated protection against oxidative injury

21 January 2018

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Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer

21 January 2018

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PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Sulforaphane improves cognitive function administered following traumatic brain injury

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

H2O2 sensing through oxidation of the Yap1 transcription factor

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

TGF-beta signaling in tumor suppression and cancer progression

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The chemical diversity and distribution of glucosinolates and isothiocyanates among plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The "Prochaska" microtiter plate bioassay for inducers of NQO1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

p53 suppresses the Nrf2-dependent transcription of antioxidant response genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

ATM activation by oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Cancer metastasis: building a framework

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Biology and biochemistry of glucosinolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Curcumin: from ancient medicine to current clinical trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

21 January 2018

Glutathione transferases

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Protection against Chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Activation of Nrf2 in defense against cadmium-induced oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Metallothioneins: zinc, cadmium, mercury, and copper thiolates and selenolates mimicking protein active site features--structural aspects and biological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Thioredoxin and thioredoxin reductase: current research with special reference to human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The transcription factor Nrf2 is a therapeutic target against brain inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Phosphorylation of tyrosine 568 controls nuclear export of Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nuclear import and export signals in control of Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

High levels of Nrf2 determine chemoresistance in type II endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Aldo-keto reductases and bioactivation/detoxication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

RsrA, an anti-sigma factor regulated by redox change

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The regulation of AP-1 activity by mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Activation of protein kinase C by tyrosine phosphorylation in response to H2O2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Regulation of yAP-1 nuclear localization in response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Regulation of the yeast Yap1p nuclear export signal is mediated by redox signal-induced reversible disulfide bond formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Inhibitory effect of fumaric acid on 3'-methyl-4-(dimethylamino)azobenzene-induced hepatocarcinogenesis in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The role of c-Jun phosphorylation in EpRE activation of phase II genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Crystal structure of the Kelch domain of human Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

An internal ribosomal entry site mediates redox-sensitive translation of Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Pathologically activated therapeutics for neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Cap-dependent and hepatitis C virus internal ribosome entry site-mediated translation are modulated by phosphorylation of eIF2alpha under oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling comp

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nomenclature for mammalian soluble glutathione transferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Induction of quinone reductase by withanolides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Inhibition of urinary bladder carcinogenesis by broccoli sprouts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

21 January 2018

Thioredoxin reductase

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Prothymosin-alpha mediates nuclear import of the INrf2/Cul3 Rbx1 complex to degrade nuclear Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

NF-kappaB: tumor promoter or suppressor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

A causal role for E-cadherin in the transition from adenoma to carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Properties and biological activities of thioredoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Increased cell migration and plasticity in Nrf2-deficient cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Drosophila kelch is an oligomeric ring canal actin organizer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Heme oxygenase-1/carbon monoxide: novel therapeutic strategies in critical care medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Oral fumaric acid esters for the treatment of active multiple sclerosis: an open-label, baseline-controlled pilot study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Cysteine-based regulation of the CUL3 adaptor protein Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Structure, regulation and function of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Electrostatic influence of local cysteine environments on disulfide exchange kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Cancer chemopreventive effects of curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

When NRF2 talks, who's listening?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Subcellular localization and cytoplasmic complex status of endogenous Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

kelch encodes a component of intercellular bridges in Drosophila egg chambers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Transcript leader regions of two Saccharomyces cerevisiae mRNAs contain internal ribosome entry sites that function in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

ERRbeta: a potent inhibitor of Nrf2 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Activity-Guided Isolation of Constituents ofTephrosia purpureawith the Potential to Induce the Phase II Enzyme, Quinone Reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Comprehensive Analysis of Proteins Which Interact with the Antioxidant Responsive Element: Correlation of ARE-BP-1 with the Chemoprotective Induction Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

A new p21waf1/cip1 isoform is an early event of cell response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0674-5

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance.

21 January 2018

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1242/JCS.074286

Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1248/CPB.51.530

Identifiers

DOI

10.1007/S00204-011-0674-5

1 reference

release_antzrp6i4reyrdi75oa74of7ae

24 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/antzrp6i4reyrdi75oa74of7ae

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

21365312

1 reference

PubMed ID

21365312