Fighting disease by selective autophagy of aggregate-prone proteins (Q37735987)

22 August 2017

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title

Fighting disease by selective autophagy of aggregate-prone proteins (English)

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22 August 2017

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Helene Knaevelsrud

1

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PubMed ID

20412801

22 August 2017

Anne Simonsen

series ordinal

2

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PubMed ID

20412801

22 August 2017

language of work or name

English

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publication date

20 April 2010

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22 August 2017

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22 August 2017

584

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22 August 2017

12

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22 August 2017

2635-2645

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Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

22 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Chaperone-mediated autophagy in aging and disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagosome formation: core machinery and adaptations

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

A Unified Nomenclature for Yeast Autophagy-Related Genes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagy fights disease through cellular self-digestion

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagy in the Pathogenesis of Disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Vesicular trafficking and autophagosome formation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

mTOR regulation of autophagy

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Two ubiquitin-like conjugation systems essential for autophagy

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Early endosomes and endosomal coatomer are required for autophagy

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Studies on the mechanisms of autophagy: maturation of the autophagic vacuole

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

ESCRTs and Fab1 regulate distinct steps of autophagy

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

PIKfyve regulation of endosome-linked pathways

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Rab7 is required for the normal progression of the autophagic pathway in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Role for Rab7 in maturation of late autophagic vacuoles

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Aggresomes, inclusion bodies and protein aggregation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Involvement of macroautophagy in the dissolution of neuronal inclusions.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The Cvt pathway as a model for selective autophagy

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Nix is a selective autophagy receptor for mitochondrial clearance

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Midbody ring disposal by autophagy is a post-abscission event of cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

p62 at the crossroads of autophagy, apoptosis, and cancer

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Transient aggregation of ubiquitinated proteins during dendritic cell maturation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Induction of autophagy and inhibition of tumorigenesis by beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Acetylation targets mutant huntingtin to autophagosomes for degradation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagy regulates the processing of amino terminal huntingtin fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagosome-like vacuole formation in Huntington's disease lymphoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

21 January 2018

Frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Dynein mutations impair autophagic clearance of aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagy, amyloidogenesis and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Intermediate filament proteins and their associated diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Toxic proteins in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Rapamycin pre-treatment protects against apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Lithium induces autophagy by inhibiting inositol monophosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

How do ESCRT proteins control autophagy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.041

10.1016/J.FEBSLET.2010.04.041

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20412801