Activity of any class IA PI3K isoform can sustain cell proliferation and survival. (Q33952917)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Activity of any class IA PI3K isoform can sustain cell proliferation and survival (English)

1 reference

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5 February 2020

3

1 reference

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5

Bart Vanhaesebroeck

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

author name string

Lazaros C Foukas

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Inma M Berenjeno

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Asim Khwaja

series ordinal

4

1 reference

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5 February 2020

language of work or name

English

0 references

publication date

7 June 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

5 February 2020

published in

1 reference

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5 February 2020

volume

107

1 reference

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5 February 2020

issue

25

1 reference

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5 February 2020

page(s)

11381-11386

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json

Regulation of phosphoinositide 3-kinase expression in health and disease

5 February 2020

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Should individual PI3 kinase isoforms be targeted in cancer?

5 July 2018

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Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma

5 July 2018

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Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest

5 July 2018

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Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages

5 July 2018

1 reference

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

5 July 2018

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

5 July 2018

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PI3K pathway alterations in cancer: variations on a theme

5 July 2018

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Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

5 July 2018

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PTEN-deficient cancers depend on PIK3CB.

5 July 2018

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Enhanced anti-cancer effect of a phosphatidylinositol-3 kinase inhibitor and doxorubicin on human breast epithelial cell lines with different p53 and oestrogen receptor status

5 July 2018

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Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

5 July 2018

1 reference

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The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

5 July 2018

1 reference

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A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

5 July 2018

1 reference

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Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

5 July 2018

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Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers

5 July 2018

1 reference

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Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase

5 July 2018

1 reference

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Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.

5 July 2018

1 reference

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Of lineage and legacy: the development of mammalian hematopoietic stem cells

5 July 2018

1 reference

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A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

5 July 2018

1 reference

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Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

5 July 2018

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Cancer-specific mutations in phosphatidylinositol 3-kinase

5 July 2018

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Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

5 July 2018

1 reference

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Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895061

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

5 July 2018

1 reference

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Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

5 July 2018

1 reference

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Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

5 July 2018

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PI 3-kinase p110beta: a new target for antithrombotic therapy

5 July 2018

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Signalling by PI3K isoforms: insights from gene-targeted mice.

5 July 2018

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

5 July 2018

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Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells

5 July 2018

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High frequency of mutations of the PIK3CA gene in human cancers

5 July 2018

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Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells

5 July 2018

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Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

5 July 2018

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Immortalization of yolk sac-derived precursor cells

5 July 2018

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Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation

5 July 2018

1 reference

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Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895061

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895061

Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895061

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895061

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895061

p110δ, a novel phosphoinositide 3-kinase in leukocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895061

Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895061

PIK3CA is implicated as an oncogene in ovarian cancer.

5 July 2018

1 reference

Crossref

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Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.

21 January 2018

1 reference

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Transforming function of the HOX11/TCL3 homeobox gene.

29 October 2018

1 reference

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Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20534549

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Competitive and noncompetitive inhibition of the DNA-dependent protein kinase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20534549

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0906461107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference