GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers (Q33963901)

30 July 2017

title

GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers (English)

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30 July 2017

main subject

cervix uterine cancer

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Ying Zhou

1

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30 July 2017

Ying Wei

2

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30 July 2017

Jing Zhu

3

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30 July 2017

Qingyuan Wang

4

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30 July 2017

Liang Bao

5

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30 July 2017

Yang Ma

6

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30 July 2017

Yu Chen

7

1 reference

30 July 2017

Dingqing Feng

8

1 reference

30 July 2017

Aijin Zhang

9

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30 July 2017

Jie Sun

10

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30 July 2017

Shreeram C Nallar

11

1 reference

30 July 2017

Keng Shen

12

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30 July 2017

Dhananjaya V Kalvakolanu

13

1 reference

30 July 2017

Weihua Xiao

14

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30 July 2017

Bin Ling

15

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30 July 2017

language of work or name

English

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publication date

12 July 2011

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30 July 2017

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30 July 2017

volume

6

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30 July 2017

issue

7

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30 July 2017

page(s)

e22065

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Creative Commons Attribution 4.0 International

30 July 2017

copyright license

start time

12 July 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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5 July 2018

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GRIM-19 and p16(INK4a) synergistically regulate cell cycle progression and E2F1-responsive gene expression

5 July 2018

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Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome

5 July 2018

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Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.

5 July 2018

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5 July 2018

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Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers

5 July 2018

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GRIM-19 inhibits v-Src-induced cell motility by interfering with cytoskeletal restructuring

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line

5 July 2018

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Effects of plasmid-based Stat3-specific short hairpin RNA and GRIM-19 on PC-3M tumor cell growth

5 July 2018

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Lysophosphatidic acid decreases the nuclear localization and cellular abundance of the p53 tumor suppressor in A549 lung carcinoma cells

5 July 2018

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The U95 protein of human herpesvirus 6B interacts with human GRIM-19: silencing of U95 expression reduces viral load and abrogates loss of mitochondrial membrane potential

5 July 2018

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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins

5 July 2018

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Evaluation of different glutathione S-transferase-tagged protein captures for screening E6/E6AP interaction inhibitors using AlphaScreen

5 July 2018

1 reference

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GRIM-19 associates with the serine protease HtrA2 for promoting cell death

5 July 2018

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The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins

5 July 2018

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Chapter 5: Updating the natural history of HPV and anogenital cancer

5 July 2018

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A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins

5 July 2018

1 reference

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Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

Role of Stat3 in regulating p53 expression and function

5 July 2018

1 reference

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Gamma interferon-inducible protein 10 induces HeLa cell apoptosis through a p53-dependent pathway initiated by suppression of human papillomavirus type 18 E6 and E7 expression.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase

5 July 2018

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Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex

5 July 2018

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The regulatory E2 proteins of human genital papillomaviruses are pro-apoptotic

5 July 2018

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The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction

5 July 2018

1 reference

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The role of TP53 in Cervical carcinogenesis.

5 July 2018

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HPV infections and lung cancer

5 July 2018

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A mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo.

5 July 2018

1 reference

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Transcriptional activity among high and low risk human papillomavirus E2 proteins correlates with E2 DNA binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death.

5 July 2018

1 reference

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5 July 2018

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Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach

5 July 2018

1 reference

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Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

Proteasome-dependent degradation of the human estrogen receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

The spectrum of mutations in UBE3A causing Angelman syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

Ubiquitin, E6-AP, and their role in p53 inactivation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

5 July 2018

1 reference

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The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

UBE3A/E6-AP mutations cause Angelman syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

The establishment of human ovarian carcinoma cell line HO-8910 and its characteristics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134474

Human papillomavirus (HPV) related carcinomas of the upper aerodigestive tract

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022065

Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022065

Preferential nuclear localization of the human papillomavirus type 16 E6 oncoprotein in cervical carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022065

The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022065

p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022065

E6AP promotes the degradation of the PML tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022065

Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022065

Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022065

A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21765936

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0022065

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference