Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool. (Q33967338)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20444706%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool (English)

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1 February 2020

6

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1 February 2020

Danny M. Hatters

7

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1 February 2020

author name string

Maya A Olshina

1

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1 February 2020

Lauren M Angley

2

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1 February 2020

Yasmin M Ramdzan

3

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1 February 2020

Jinwei Tang

4

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1 February 2020

Michael F Bailey

5

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1 February 2020

language of work or name

English

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publication date

5 May 2010

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Journal of Biological Chemistry

1 February 2020

published in

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1 February 2020

volume

285

1 reference

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1 February 2020

issue

28

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1 February 2020

page(s)

21807-21816

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20444706%20AND%20SRC:MED&resulttype=core&format=json

Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo

1 February 2020

cites work

1 reference

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Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

5 July 2018

1 reference

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Secondary Structure of Huntingtin Amino-Terminal Region

5 July 2018

1 reference

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Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease

5 July 2018

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Single homopolypeptide chains collapse into mechanically rigid conformations

5 July 2018

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Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery

5 July 2018

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Fluorescence detection of a lipid-induced tetrameric intermediate in amyloid fibril formation by apolipoprotein C-II.

5 July 2018

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Protein misfolding inside cells: the case of huntingtin and Huntington's disease

5 July 2018

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The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation

5 July 2018

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Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

5 July 2018

1 reference

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Modulation of polyglutamine inclusion formation by the Hsp70 chaperone machine.

5 July 2018

1 reference

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Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions

5 July 2018

1 reference

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Flanking sequences profoundly alter polyglutamine toxicity in yeast

5 July 2018

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Protein misfolding, functional amyloid, and human disease

5 July 2018

1 reference

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HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

5 July 2018

1 reference

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Opinion: What is the role of protein aggregation in neurodegeneration?

5 July 2018

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Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells

5 July 2018

1 reference

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

5 July 2018

1 reference

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Fluorescence detection for the XLI analytical ultracentrifuge

5 July 2018

1 reference

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An improved cyan fluorescent protein variant useful for FRET

5 July 2018

1 reference

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Sedimentation velocity analysis of flexible macromolecules: self-association and tangling of amyloid fibrils

5 July 2018

1 reference

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Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

5 July 2018

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A linear lattice model for polyglutamine in CAG-expansion diseases

5 July 2018

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Modern analytical ultracentrifugation in protein science: a tutorial review

5 July 2018

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Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems

5 July 2018

1 reference

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Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

5 July 2018

1 reference

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Aggresomes, inclusion bodies and protein aggregation

5 July 2018

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

5 July 2018

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

5 July 2018

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

5 July 2018

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

5 July 2018

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Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

5 July 2018

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5 July 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

5 July 2018

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

5 July 2018

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Crystal structure of the Aequorea victoria green fluorescent protein

5 July 2018

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Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.

5 July 2018

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Molecular chaperones in cellular protein folding

5 July 2018

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Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

5 July 2018

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Detection of polyglutamine protein oligomers in cells by fluorescence correlation spectroscopy

21 January 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

21 January 2018

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Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

21 January 2018

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The crystal structure of the Y66L variant of green fluorescent protein supports a cyclization-oxidation-dehydration mechanism for chromophore maturation

21 January 2018

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Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

21 January 2018

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Human apolipoprotein C-II forms twisted amyloid ribbons and closed loops.

21 January 2018

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The molecular chaperone, alpha-crystallin, inhibits amyloid formation by apolipoprotein C-II.

21 January 2018

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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

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Huntingtin and mutant SOD1 form aggregate structures with distinct molecular properties in human cells

21 January 2018

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Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease

21 January 2018

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Modeling polyglutamine pathogenesis in C. elegans

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20444706

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Polyglutamine protein aggregates are dynamic

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20444706

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20444706

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.084434

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20444706%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20444706%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference